Cerebral sinovenous thrombosis in the neonate

Archives of Neurology
Karima C FitzgeraldMeredith R Golomb

Abstract

There are few studies on neonatal cerebral sinovenous thrombosis (SVT). To describe the presentations, treatments, and outcomes of neonatal SVT and to assess infarction as a predictor of outcome. Retrospective chart study. A tertiary pediatric hospital in Indianapolis, Ind. Patients Forty-two children with neonatal SVT identified using International Classification of Diseases, Ninth Revision code searches from 1986 through June 2005 and review of neurology clinic records. None. Cognitive impairment, motor impairment, and epilepsy at last clinic visit. Gestational or delivery complications or risk factors and comorbid conditions such as dehydration, sepsis, and cardiac defects were common (gestational/delivery factors in 82% [31 of 38 with available maternal data]; comorbid conditions in 62% [26 of the 42]). Twenty-four (57%) presented with seizures. Twenty-five (60%) had infarcts, which were hemorrhagic in 22. Only 27 (64%) of 42 received prothrombotic evaluations; none had persistent deficiencies of protein C, protein S, or antithrombin III. Three (7%) received heparin sodium. All other children received only supportive care. One child died. Outcome data were available for 29 (71%) of the 41 survivors; of these, 23 (79%) had i...Continue Reading

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