Cerebral sinus thrombosis: rapid test diagnosis by demonstration of increased plasma D-dimer levels (SimpliRED)

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
J E WildbergerD Vorwerk

Abstract

To perform an initial evaluation of the accuracy in detection of dural sinus and cerebral venous thrombosis using a bed-side test (SimpliRED). Early diagnosis and treatment of cerebral sinus thrombosis are important. A screening test to decide which patients should undergo further diagnostics would be valuable due to the low incidence. Six patients with MR proven cerebral sinus thrombosis underwent bed-side testing. The SimpliRED kit provides a clearly visible agglutination of the patient's red blood cells in the presence of elevated levels of the crosslinked fibrin derivative (D-dimer) in the sample. The assay yielded a positive result in all six patients, even 56 days following the onset of clinical symptoms. The sensitivity of SimpliRED in the detection of sinus venous thrombosis is not known. This assay, therefore, should be evaluated in a large prospective study. In addition, the capability of the test to assess the effect of and predict the duration of anticoagulation therapy should be considered.

Citations

Aug 19, 2008·Acta Neurologica Scandinavica·E Haapaniemi, T Tatlisumak
Mar 20, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Ran MengXunming Ji
Feb 5, 2011·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN American Heart Association Stroke Council and the Council on Epidemiology and Prevention
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Christoph M KosinskiJohannes Schiefer
Apr 29, 1998·Investigative Radiology·J E WildbergerR W Günther
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·B CucchiaraE Pollak

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