Cerebral spectroscopic and oxidative stress studies in patients with schizophrenia who have dangerously violently offended.

BMC Psychiatry
Ian H Treasaden, B K Puri

Abstract

The aim of this study was to bring together all the results of in vivo studies of ethane excretion and cerebral spectroscopy in patients with schizophrenia who have dangerously seriously violently offended in order to determine the extent to which they shed light on the degree to which the membrane phospholipid hypothesis and the actions of free radicals and other reactive species are associated with cerebral pathophysiological mechanisms in this group of patients. The patients investigated were inpatients from a medium secure unit with a DSM-IV-TR diagnosis of schizophrenia. There was no history of alcohol dependency or any other comorbid psychoactive substance misuse disorder. Expert psychiatric opinion, accepted in court, was that all these patients had violently offended directly as a result of schizophrenia prior to admission. These offences consisted of homicide, attempted murder or wounding with intent to cause grievous bodily harm. Excreted ethane was analyzed and quantified by gas chromatography and mass spectrometry (m/z = 30). 31-phosphorus magnetic resonance spectroscopy data were obtained at a magnetic field strength of 1.5 T using an image-selected in vivo spectroscopy sequence (TR = 10 s; 64 signal averages local...Continue Reading

References

Jan 1, 1996·Progress in Biophysics and Molecular Biology·I J Cox
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Jun 8, 2001·Magma·A NaressiD Graveron-Demilly
Dec 31, 2005·Schizophrenia Bulletin·Kris Naudts, Sheilagh Hodgins
Jan 1, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Basant K PuriIan H Treasaden
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Basant K PuriIan H Treasaden

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Citations

Feb 24, 2012·Molecules and Cells·Cana Park, Sang Ki Park
May 9, 2008·BMC Psychiatry·Basant K Puri
May 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Larissa de OliveiraAlexandra I Zugno

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Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

SPSS
MRUI

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