Cerebral tissue oximetry levels during prehospital management of cardiac arrest - A prospective observational study

Resuscitation
Gregor ProsenDušan Mekiš

Abstract

Near-infrared spectroscopy (NIRS) enables continuous monitoring of regional oximetry (rSO2). The aim of this study was to describe dynamics of regional cerebral oximetry levels during out of hospital cardiac arrest (OHCA) resuscitation, specifically around the time of restoration of spontaneous circulation (ROSC). This prospective observational study was performed in the prehospital setting during cardio-pulmonary resuscitation (CPR) of OHCA patients. In the three-year study period, two-hundred eighty OHCA's were responded to; rSO2 was continuously measured throughout CPR and after attaining ROSC. Final data analysis included 53 patients. Continuous rSO2dynamics were described and data was compared amongst ROSC (22 cases) and no-ROSC (31 cases) groups. Initial rSO2levels were below 15% (not detectable) in both groups. With ongoing CPR, rSO2levels were higher in the ROSC group (median 22% vs. 14% in no-ROSC group, p = 0.030). Until ROSC, rSO2levels were higher throughout CPR before ROSC (mean maximal value 47% at ROSC vs. 31% no-ROSC, p < 0.01). Furthermore, we found a pattern of significant, rapid and sustained rise in rSO2levels minutes prior to ROSC and normalization thereafter. Initial rSO2levels during OHCA are generally un...Continue Reading

Citations

Mar 7, 2019·Intensive Care Medicine·Claudio SandroniJerry P Nolan
Feb 6, 2020·Experimental and Therapeutic Medicine·Chunshuang WuMao Zhang
Jul 12, 2020·Internal and Emergency Medicine·Simone SavastanoAlessandra Palo
Nov 3, 2020·Journal of Physical Therapy Science·Yuji Maruyama
Mar 6, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Jumpei TsukudaYasuhiko Taira
Apr 15, 2021·Seminars in Neurology·Giovanni ChiariniRoberto Lorusso
Nov 16, 2021·Annals of the New York Academy of Sciences·Elise L Huppert, Sam Parnia

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