PMID: 8584622Oct 1, 1995Paper

Cerebral tryptophan hydroxylase activity, and 5-HT1A receptor, 5-HT2A receptor, and 5-HT transporter binding in grouped and isolated Roman RHA and RLA rats: relationships with behaviours in two models of anxiety

Psychopharmacology
A KulikovF Chaouloff

Abstract

Male Roman low-(RLA) and high-avoidance (RHA) rats differ when tested in the elevated plus-maze and the black/white box, but not when (isolated and) tested for their social interaction. Herein, we have analysed the impact of prior isolation on male Roman rats tested in the first two models of anxiety; moreover, because central serotonin (5-HT) systems in Roman rats have been scarcely studied, we have also analysed several anxiety-related indices of central serotonergic activity in grouped/isolated Roman rats. Group-housed RLA rats tested in the elevated plus-maze and the black/white box were less anxious than their RHA counterparts, thereby confirming our previous study. Isolation had anxiogenic (and hypolocomotor) effects, these being significant in RLA rats only. Tryptophan hydroxylase activity in midbrain (but not in cortex, hippocampus or hypothalamus) was lower in group-housed (but not in isolated) RLA rats than in RHA rats, a difference independent from changes in the regulatory properties of the enzyme. Neither midbrain and hippocampal [3H]8-hydroxy-2-(di-n-propylamino)-tetrlin binding at 5-HT1A receptors, nor midbrain [3H] citalopram binding at the 5-HT transporter was different between grouped/isolated RHA/RLA rats. Al...Continue Reading

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Citations

Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Mar 10, 2001·Physiology & Behavior·S KantorG Bagdy
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·A Ramos, P Mormède
Feb 5, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·M SteciukF Petty
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margarita MorenoPilar Flores
Dec 26, 2001·Annual Review of Psychology·John C Crabbe

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