Cerebral vasospasm after aneurysmal subarachnoid hemorrhage and traumatic brain injury

Current Treatment Options in Neurology
Saef Izzy, Susanne Muehlschlegel

Abstract

Cerebral vasospasm (cVSP) consists of the vasoconstriction of large and small intracranial vessels which can lead to cerebral hypoperfusion, and in extreme cases, delayed ischemic deficits with stroke. While most commonly observed after aneurysmal subarachnoid hemorrhage (aSAH), cVSP can also occur after traumatic brain injury (TBI) as we have described in detail in this review. For the past decades, the research attention has focused on cVSP because of its association with delayed cerebral ischemia, which is the largest contributor of morbidity and mortality after aSAH. New discoveries in the cVSP pathophysiology involving multifactorial complex cascades and pathways pose new targets for therapeutic interventions in the prevention and treatment of cVSP. The goal of this review is to demonstrate the commonalities and differences in epidemiology and pathophysiology of both aSAH and TBI-associated cVSP, and highlight the more recently discovered pathways of cVSP. Finally, the latest cVSP surveillance methods and treatment options are illustrated.

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·R L Macdonald, B K Weir
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·T YamajiM Fujino
Jan 1, 1989·Acta neurochirurgica·K F LindegaardP Nakstad
Jun 1, 1970·Journal of Neurosurgery·R H Wilkins, G L Odom
Oct 1, 1993·Journal of Neurosurgery·I YamauraY Maeda
Apr 18, 1998·Electroencephalography and Clinical Neurophysiology·P M VespaD P Becker
Mar 6, 1999·Stroke; a Journal of Cerebral Circulation·G RordorfA G Sorensen
Jan 6, 2000·The New England Journal of Medicine·J A Edlow, L R Caplan
Mar 14, 2000·Surgical Neurology·A Y ZubkovA D Parent
Jan 11, 2000·Stroke; a Journal of Cerebral Circulation·K FassbenderM Hennerici
Sep 6, 2002·Biochemical Pharmacology·Gregg Semenza
May 24, 2003·Stroke; a Journal of Cerebral Circulation·Hisanobu TsurutaniShigeharu Suzuki
Jun 26, 2003·Neurosurgery·Aaron S DumontKevin S Lee
Mar 25, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Navraj S HeranBrian D Toyota
Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Alejandro A RabinsteinEelco F M Wijdicks
Aug 24, 2004·Current Vascular Pharmacology·Eiichi Tani, Tsuyoshi Matsumoto
Apr 5, 2005·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jan ClaassenLawrence J Hirsch
Apr 16, 2005·Stroke; a Journal of Cerebral Circulation·Alejandro A RabinsteinEelco F M Wijdicks

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Citations

Feb 15, 2001·Critical Care : the Official Journal of the Critical Care Forum·K IkedaT Fukuda
Mar 8, 2016·The American Journal of Emergency Medicine·John PapanikolaouEpaminondas Zakynthinos
Nov 28, 2015·Current Opinion in Pharmacology·Nikolaus Plesnila
Mar 8, 2016·Neurotoxicology·Giulia Alessandra WiggersMaría Jesús Alonso
Apr 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arjang SalehiAndre Obenaus
Apr 4, 2017·Journal of Anatomy·Arjun BurlakotiMaciej Henneberg
May 18, 2019·Translational Neuroscience·Georg VadokasThomas Westermaier
Oct 28, 2017·Journal of Neurosurgery·Hormuzdiyar H DasenbrockRose Du
Apr 7, 2018·Frontiers in Molecular Neuroscience·Jenna L LeclercSylvain Doré
Feb 23, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pavlos MyserlisChristopher D Anderson

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