Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Leonor DiasMarta Carvalho

Abstract

The development of SARS-CoV-2 vaccines has raised several concerns regarding venous thromboembolism, namely cerebral venous thrombosis. Although cerebral venous thrombosis has been reported after administration of a viral vector vaccine, due to a possible auto-immune mechanism inducing thrombocytopenia, the same has not happened in mRNA vaccines. We report two cases of cerebral venous thrombosis, shortly after administration of mRNA vaccine. In both patients, there was no evidence of thrombocytopenia or antiplatelet antibodies, and alternative causes for cerebral venous thrombosis were found. As such, despite the temporal relation of both cases to vaccine administration, these types of cerebral venous thrombosis do not seem to be pathophysiological different from cerebral venous thrombosis not associated to SARS-CoV-2 vaccination. Continuous pharmacovigilance is necessary to monitor possible new events and clarify this association.

References

Dec 11, 2020·The New England Journal of Medicine·Fernando P PolackUNKNOWN C4591001 Clinical Trial Group
Apr 3, 2021·Lancet·Søren Dinesen ØstergaardHenrik Toft Sørensen
Apr 15, 2021·The New England Journal of Medicine·Kate-Lynn MuirKrishna Gundabolu
Apr 17, 2021·The New England Journal of Medicine·Marie ScullyWilliam Lester
May 1, 2021·JAMA : the Journal of the American Medical Association·Isaac SeeKaren R Broder

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Citations

Jun 17, 2021·American Journal of Hematology·Bingwen Eugene FanBanumukala Madhava Rao Vishnu Prasad
Jul 21, 2021·Circulation·Biykem BozkurtPeter J Hotez
Aug 18, 2021·BMJ Case Reports·Luís Lourenço GraçaBeatriz Costa
Aug 30, 2021·Trends in Cardiovascular Medicine·Toshiaki Iba, Jerrold H Levy
Sep 4, 2021·JAMA : the Journal of the American Medical Association·Kimberly G BlumenthalDavid W Bates
Nov 17, 2021·Acta neurochirurgica·Ryuhei TakeyamaTooru Inoue

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