Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats

Brain Research Bulletin
Javad MahmoudiFereshteh Farajdokht

Abstract

Chronic migraine dramatically affects the quality of life in the migraineurs. This study examined the effect of chronic cerebrolysin (CBL) treatment on the migraine-associated symptoms in a rat model of migraine. Experiments were carried out on 8 weeks, male Wistar rats. Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9. CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days. Mechanical and thermal withdrawal thresholds of the hind paw were examined by von Frey hairs and hot plate, respectively. Head grooming behavior was evaluated one hour following injection of NTG. Light-aversive behaviors were determined in the modified elevated plus-maze (EPM) on even days and in the light/dark box on odd days. After behavioral experiments, blood concentrations of calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), tumor necrosis factor-a (TNF-α), and interleukin-1β (IL-1β) were assessed by rat specific enzyme-linked immunosorbent assay (ELISA) kits. Our results indicated that NTG significantly increased migraine-related behavioral and molecular symptoms in the animals, whereas CBL treatment markedly reduced mechanical and thermal ...Continue Reading

Citations

Feb 24, 2019·Reviews in the Neurosciences·Ava NasrolahiJavad Mahmoudi
May 1, 2019·The Journal of Headache and Pain·Tamás KörtésiJános Tajti
Aug 5, 2019·Molecular Neurobiology·Yuanyuan TangFeng Tao
Dec 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A GromovaK S Ostrenko
Jun 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaobai XuLinpeng Wang
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A GromovaO V Tikhonova

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