Cerebrolysin dose-dependently improves neurological outcome in rats after acute stroke: A prospective, randomized, blinded, and placebo-controlled study

International Journal of Stroke : Official Journal of the International Stroke Society
Li ZhangZheng Gang Zhang

Abstract

Cerebrolysin is a mixture of neuropeptides and free amino acids that is clinically used for the treatment of stroke. To further standardize treatment schemes, we assessed the dose response of Cerebrolysin on sensorimotor outcome in a rat model of ischemic stroke. This study was a prospective, blinded, placebo-controlled, preclinical experiment. Male and female Wistar rats, subjected to embolic middle cerebral artery occlusion, were randomly treated with Cerebrolysin doses of 0.8, 2.5, 5.0, 7.5 ml/kg or placebo, 4 h after middle cerebral artery occlusion for a total of 10 consecutive days. The primary outcome was neurologic improvement at day 28, lesion volume, mortality, and animal weight were secondary and safety outcomes, respectively. There was a significant (p < 0.001) dose effect of Cerebrolysin on neurological outcome. Cerebrolysin at a dose of ≥ 2.5 ml/kg significantly (p < 0.001) improved neurological outcome (Mean Estimate (95% CL): 0.8 ml/kg: 6.2 (-6.0/18.4), 2.5 ml/kg: -28.9 (-41.6/-16.2), 5.0 ml/kg: -33.4 (-45.0/-21.7), 7.5 ml/kg: -36.3 (-48.2/-24.4). Higher doses (≥ 2.5 ml/kg) resulted in better recovery; however, differences between effective doses were not significant. Treatment with 5 ml/kg reduced lesion volume...Continue Reading

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Citations

Apr 7, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Li ZhangZheng G Zhang
Feb 14, 2019·Journal of Cellular Physiology·Javad MahmoudiSiamak Sandoghchian Shotorbani
Dec 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N Bogolepova
Jun 4, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N Bogolepova, O S Levin
Jan 1, 2021·Expert Opinion on Pharmacotherapy·Adithya KannanE Sander Connolly
May 7, 2021·Neurorehabilitation and Neural Repair·Scott R DeBoerSteven R Zeiler
Aug 31, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D V KurkinV I Petrov

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