Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat

Annals of the New York Academy of Sciences
Hari Shanker SharmaConrad Johanson

Abstract

Traumatic brain injuries (TBIs) induce profound breakdown of the blood-brain and blood-cerebrospinal fluid barriers (BCSFB), brain pathology/edema, and sensory-motor disturbances. Because neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and glial cell-derived neurotrophic factor (GDNF), are neuroprotective in models of brain and spinal cord injuries, we hypothesized that a combination of neurotrophic factors would enhance neuroprotective efficacy. In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI. TBI was produced under Equithesin (3 mL/kg, i.p.) anesthesia by making a longitudinal incision into the right parietal cerebral cortex. Untreated injured rats developed profound disruption of the blood-brain barrier (BBB) to proteins, edema/cell injury, and marked sensory-motor dysfunctions on rota-rod and grid-walking tests at 5 h TBI. Intracerebroventricular administration of Cerebrolysin (10 or 30 microL) either 5 min or 1 h after TBI significantly reduced leakage of Evans blue and radioiodine tracers across the...Continue Reading

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Citations

Jul 11, 2013·PloS One·Gehan S GeorgyDalaal M Abdallah
Jan 1, 2014·European Journal of Pharmacology·Waleed BarakatMohamed N M Zakaria
Sep 11, 2014·Neural Regeneration Research·Xue YaoYanshu Zhang
Jun 14, 2014·The Kaohsiung Journal of Medical Sciences·Tzu-Lun HuangRong-Kung Tsai
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Aug 25, 2017·Journal of Neuroscience Research·Bellal JosephPeter Rhee
Apr 13, 2018·Journal of Neurotrauma·Hong-Liang Zhang, Jiang Wu
Jan 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dafin F MuresanuJohannes Vester
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Aug 16, 2019·Environmental Research·Joanna A RuszkiewiczMichael Aschner
Jan 31, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Brian FianiErika Sarno
Jun 15, 2021·Environmental Research·Paolo BongioanniRoberto Buizza
Apr 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenqi JinLiwei Sun

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