Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors

The Journal of Steroid Biochemistry and Molecular Biology
Xiaoyan ZhuRachida Guennoun

Abstract

Treatment with progesterone limits brain damage after stroke. However, the cellular bases of the cerebroprotective effects of progesterone are not well documented. The aims of this study were to determine neural cells and functions that are affected by progesterone treatment and the role of neural progesterone receptors (PR) after stroke. Adult male PRNesCre mice, selectively lacking PR in the central nervous system, and their control PRloxP/loxP littermates were subjected to transient ischemia by middle cerebral artery occlusion (MCAO) for 30 min. Mice received either progesterone (8 mg/kg) or vehicle at 1-, 6- and 24- hrs post-MCAO and outcomes were analyzed at 48 h post-MCAO. In PRloxP/loxP mice, progesterone exerted multiple effects on different neural cell types, improved motor functional outcomes and reduced total infarct volumes. In the peri-infarct, progesterone increased the density of neurons (NeuN+ cells), of cells of the oligodendroglial lineage (Olig2+ cells) and of oligodendrocyte progenitors (OP, NG2+ cells). Progesterone decreased the density of activated astrocytes (GFAP+ cells) and reactive microglia (Iba1+ cells) coexpressing the mannose receptor type 1 CD206 marker. Progesterone also reduced the expression o...Continue Reading

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Citations

Oct 12, 2018·Cellular and Molecular Neurobiology·Rachida GuennounMichael Schumacher
Jan 23, 2020·Journal of Clinical Medicine·Tereza FilipiAnd Miroslava Anderova
May 30, 2020·International Journal of Molecular Sciences·Claudia Espinosa-GarciaDonald G Stein
Jul 30, 2020·International Journal of Molecular Sciences·Rachida Guennoun
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Regine Sitruk-WareCesar V Borlongan
Jan 9, 2021·Therapeutic Advances in Neurological Disorders·Clare LambertRamin Zand
Mar 7, 2021·Biomolecules·Jocelyn M BretonDaniela Kaufer
Aug 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zeinab VahidiniaMohammad Taghi Joghataei

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