Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123 I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease

Journal of Neural Transmission
Hidetomo MurakamiKenjiro Ono

Abstract

We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using 123I-Ioflupane SPECT and 123I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = - 0.642, p < 0.01) of 123I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.

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Citations

Apr 21, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hidetomo MurakamiYasuyuki Iguchi

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