Cerebrospinal fluid and plasma disposition of yohimbine and 11-hydroxy-yohimbine in young and older healthy subjects, and Alzheimer's disease patients

European Journal of Clinical Pharmacology
P Le CorreR Le Verge

Abstract

The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg.kg-1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD). Plasma disposition of YO displayed large variability; no significant differences among subject groups were observed. In contrast, 11-OH-YO Cmax and AUC were significantly lower in the older normal subjects than in the young normal or AD subjects. A strong positive correlation between CSF and plasma YO concentrations was observed. A weak positive correlation between CSF and plasma concentrations of 11-OH-YO was also observed. CSF to plasma concentration ratios for yohimbine and 11-OH-YO were low (approximately 2%).

Citations

Dec 18, 2001·Pharmacology & Therapeutics·S W TamM Wyllie
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Le CorreR Le Verge
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E C PetrieM A Raskind
May 4, 2005·Biological Psychiatry·Alan C SwannF Gerard Moeller
Jan 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Adjmal NahimiAlbert Gjedde

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