Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage

Journal of Alzheimer's Disease : JAD
Brianne M BettcherJoel H Kramer


Inflammatory markers have been shown to predict neurocognitive outcomes in aging adults; however, the degree to which peripheral markers mirror the central nervous system remains unknown. We investigated the association between plasma and cerebrospinal fluid (CSF) markers of inflammation, and explored whether these markers independently predict CSF indicators of Alzheimer's disease (AD) pathology or neuronal damage. Plasma and CSF samples were analyzed for inflammatory markers in a cohort of asymptomatic older adults (n = 173). CSF samples were analyzed for markers of AD pathology (Aβ42, phosphorylated tau [p-tau], sAβPPβ) or neuronal damage (total tau; neurofilament light chain) (n = 147). Separate linear models for each analyte were conducted with CSF and plasma levels entered simultaneously as predictors and markers of AD pathology or neuronal damage as outcome measures. Strong associations were noted between CSF and plasma MIP-1β levels, and modest associations were observed for remaining analytes. With respect to AD pathology, higher levels of plasma and CSF IL-8, CSF MIP-1β, and CSF IP-10 were associated with higher levels of p-tau. Higher levels of CSF IL-8 were associated with higher levels of CSF Aβ42. Higher CSF sAβPP...Continue Reading


Sep 5, 2002·Annals of Neurology·Reinhold SchmidtLenore J Launer
Jan 25, 2003·Annals of Clinical Biochemistry·M M VerbeekH P H Kremer
Jun 27, 2003·Dementia and Geriatric Cognitive Disorders·Yong-Xin SunS Janciauskiene
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·E TarkowskiK Blennow
Apr 27, 2005·Neurology·M G DikP Eikelenboom
Nov 26, 2005·Neurobiology of Aging·Daniela GalimbertiElio Scarpini
Apr 12, 2006·Archives of Neurology·Daniela GalimbertiElio Scarpini
Nov 27, 2007·Journal of Neuroimmunology·Konstantinos BonotisStavros Baloyannis
Feb 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dawn E AlleyTeresa E Seeman
Sep 9, 2008·Psychoneuroendocrinology·David GimenoArchana Singh-Manoux
Mar 1, 2008·Current Aging Science·Daniela GalimbertiElio Scarpini
Feb 18, 2010·Neuro-degenerative Diseases·Piet EikelenboomWillem A van Gool
Oct 12, 2010·Journal of Alzheimer's Disease : JAD·Breno Satler DinizOrestes Vicente Forlenza
Apr 8, 2011·Journal of Alzheimer's Disease : JAD·Sonia ChalbotKhalid Iqbal
Aug 17, 2011·Brain, Behavior, and Immunity·Brianne Magouirk BettcherJoel H Kramer
May 9, 2012·TheScientificWorldJournal·Jose Miguel Rubio-Perez, Juana Maria Morillas-Ruiz
Jun 1, 2012·Alzheimer's Research & Therapy·Piet EikelenboomWillem A van Gool
Dec 4, 2012·Autoimmunity Reviews·Saul A Villeda, Tony Wyss-Coray
Feb 22, 2014·Dementia and Geriatric Cognitive Disorders·Rebecca L KoscikMark A Sager
Jul 11, 2014·Clinical Pharmacology and Therapeutics·B M Bettcher, J H Kramer
Jan 3, 2015·Neurobiology of Aging·Brianne Magouirk BettcherUNKNOWN Health ABC study
Apr 3, 2015·Brain : a Journal of Neurology·Nicole MaphisKiran Bhaskar
May 17, 2015·EMBO Molecular Medicine·Luis F MaiaMathias Jucker
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
Jan 17, 2017·Nature Immunology·Britta EngelhardtRoy O Weller

❮ Previous
Next ❯


Jul 26, 2018·Future Medicinal Chemistry·Nikolay T Tzvetkov, Atanas G Atanasov
Nov 8, 2018·Journal of Alzheimer's Disease : JAD·Keenan A WalkerRebecca F Gottesman
Nov 30, 2018·Acta Neuropathologica·José Luis MolinuevoKaj Blennow
Mar 1, 2019·Frontiers in Aging Neuroscience·Brianne M BettcherJoel H Kramer
Sep 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cutter A LindberghJoel H Kramer
Oct 6, 2020·Journal of Alzheimer's Disease : JAD·Paula Duarte-GutermanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 10, 2020·Journal of Personalized Medicine·Eva AusóGema Esquiva
Jul 2, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jacopo Meldolesi
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Dec 15, 2020·International Journal of Epidemiology·Chris Ho Ching Yeung, C Mary Schooling
Nov 19, 2020·International Journal of Environmental Research and Public Health·Yu-Ming WuYing-Hsuan Tai
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
May 14, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David G Morgan, Michelle M Mielke
Jun 9, 2021·Translational Neurodegeneration·Mari AksnesAnne-Brita Knapskog
Jun 3, 2021·International Journal of Molecular Sciences·Tsuyoshi NakaiHiroyuki Mizoguchi
Jun 5, 2021·Neurobiology of Disease·Miguel A PappollaBurkhard Poeggeler
Jun 8, 2021·Journal of Psychosomatic Research·Suzanne S DunneColum P Dunne
Jul 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Anurag Kumar SinghM P Singh
Sep 24, 2020·Behavioural Neurology·Tingting PiJingshan Shi
Jan 9, 2022·Alzheimer's Research & Therapy·Juan Luis Sanchez-SanchezUNKNOWN MAPT/DSA Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Donata PaternicòGiovanni B Frisoni
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Argonde C van HartenWiesje M van der Flier
© 2022 Meta ULC. All rights reserved