Cerebrospinal fluid and serum antiphospholipid antibodies in multiple sclerosis, Guillain-Barré syndrome and systemic lupus erythematosus

Arquivos de neuro-psiquiatria
P E MarchioriR M De Oliveira

Abstract

Immunoglobulins isotypes (IgG and IgM) for myelin basic protein (MBP), cerebrosides (CER), gangliosides (GANG) and cardiolipin (CARD) were detected in the cerebrospinal fluid (CSF) from 33 patients with multiple sclerosis (MS), 18 with Guillain-Barré syndrome (GBS) and 30 with systemic lupus erythematosus (SLE). In MS patients occurred positive and significant levels of IgG-MBP in 51.5% (p less than 0.05) and IgM-MBP in only 18.2%, IgG-CARD in 46.2%, as long as CER and GANG were detected in almost 20%. From serum samples of MS patients 20.6% presented IgG-MBP, while 53% showed positive levels for IgM-MBP. The CSF analysis of patients with GBS showed that 56.3% revealed IgG-MBP (p less than 0.05), 53% for IgM-MBP, 38.5% for IgG-CER and 23% for IgM-CER, while 50% of patients had IgG-CARD, as long as 31% also had IgG-GANG. The serum evaluation from 14 patients showed that 18.8% had positive concentrations of IgG-MBP and 56.3% presented IgM-MBP (p less than 0.05). Except for 50% of patients with SLE who presented positive CSF levels of IgG-CARD, only 24.1% had positive levels of IgG-MBP. We believe that the presence of antiphospholipid antibodies in CSF of the above mentioned diseases occurred as immune epiphenomena, but their appe...Continue Reading

References

Dec 10, 1983·Lancet·E N HarrisA Gharavi
Apr 1, 1984·Biochemical Society Transactions·C R Alving
May 1, 1980·Journal of the Neurological Sciences·R ArnonW W Tourtellotte
Dec 1, 1980·The Journal of Clinical Investigation·T HiranoK Okumura
Nov 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·M YOKOYAMAR O BRADY

❮ Previous
Next ❯

Citations

Mar 10, 2009·Journal of Neurology·Johannes BrettschneiderHayrettin Tumani
Jul 27, 2001·Current Rheumatology Reports·D Tanne, S Hassin-Baer
Dec 3, 2016·Seminars in Arthritis and Rheumatism·Mira MerashliPaul R J Ames
Jan 5, 2000·Multiple Sclerosis : Clinical and Laboratory Research·S MatàH Link
Dec 3, 2016·The International Journal of Biochemistry & Cell Biology·Shaoni Dasgupta, Subhajit Dasgupta
Aug 21, 2009·Multiple Sclerosis : Clinical and Laboratory Research·M Podbielska, E L Hogan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.