Abstract
Nitric oxide is hypothesised to play a role in the immunopathogenesis of multiple sclerosis. Raised cerebrospinal fluid and serum levels of the nitric oxide metabolites nitrate and nitrite have been described in patients with multiple sclerosis. Cerebrospinal fluid and serum nitrate and nitrite were measured in patients with multiple sclerosis, inflammatory and non-inflammatory neurological diseases, and correlated with the albumin quotient, an index of blood-brain-barrier dysfunction. Patients undergoing diagnostic lumbar and vene puncture were prospectively recruited, clinical data were obtained from the hospital records, and the CSF and serum nitrate and nitrite levels were measured by the nitrate reductase and Griess reaction methods. Nitrate and nitrite, were raised in the CSF and serum of patients with multiple sclerosis and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P < 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively). CSF nitrate and nitrite levels correlated with the albumin quotient (n = 59, r = 0.42, P < 0.001). This study pro...Continue Reading
References
Aug 7, 1992·Brain Research·K M Boje, P K Arora
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Nov 15, 1982·Klinische Wochenschrift·K FelgenhauerM Nekic
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 1, 1994·Annals of Neurology·L BöB D Trapp
Mar 1, 1995·The American Journal of Physiology·R B MateoJ E Albina
Oct 1, 1995·Infection and Immunity·B L BusterW M Scheld
Aug 28, 1995·FEBS Letters·S Inoue, S Kawanishi
Jul 1, 1993·Journal of Neuroimmunology·S C LeeC F Brosnan
May 1, 1995·Journal of Neurochemistry·J P BolañosJ B Clark
Apr 25, 1995·Biochemistry·B RoyM Fontecave
Jan 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·A W JohnsonS J Heales
Aug 1, 1994·Neuroscience·B MitrovicJ E Merrill
Sep 1, 1994·Journal of Neurochemistry·S MilstienM P Heyes
Mar 1, 1993·Journal of Neuroimmunology·M K ShariefE J Thompson
Aug 21, 1995·Neuroreport·A ShuklaR C Srimal
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BagasraH Koprowski
Apr 1, 1996·Journal of Cellular Physiology·R D Hurst, I B Fritz
Apr 1, 1996·Neurology·F D Lublin, S C Reingold
May 13, 1996·Brain Research·K M Boje
Jan 1, 1996·Developmental Neuroscience·J E BarkerS J Heales
Mar 1, 1997·Annals of Clinical Biochemistry·G GiovannoniS J Heales
Citations
Jan 14, 1999·Endocrinology·S H Yen, J T Pan
Feb 16, 1999·Brain Pathology·K J SmithP A Felts
Nov 11, 2006·Neuroepidemiology·Tatjana PekmezovicJelena Kostic
Sep 26, 2007·Multiple Sclerosis : Clinical and Laboratory Research·K RejdakG Giovannoni
Feb 27, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Violaine K HarrisSaud A Sadiq
Apr 26, 2001·Multiple Sclerosis : Clinical and Laboratory Research·J DrulovićM Mostarica Stojokvić
Mar 30, 2007·Journal of Neural Transmission·K RejdakZ Stelmasiak
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Marcus KochJacques De Keyser
May 26, 2020·Journal of Neural Transmission·José A G AgúndezFélix Javier Jiménez-Jiménez
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Oct 12, 1999·Multiple Sclerosis : Clinical and Laboratory Research·G GiovannoniE J Thompson
Oct 31, 2002·Journal of Neuroscience Research·Vittorio CalabreseGiovanni Pennisi
Aug 4, 2018·Journal of Neurotrauma·Steve CashaV Wee Yong
Feb 8, 2021·Journal of Neuroimmunology·Duygu Eryavuz OnmazAli Unlu
Feb 13, 2004·Biological Psychiatry·Thayne L SweetenChristopher J McDougle
Feb 10, 2007·Analytical Chemistry·Chia-Jui KuDana Spence