PMID: 9532589Apr 9, 1998Paper

Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
G Giovannoni

Abstract

Nitric oxide is hypothesised to play a role in the immunopathogenesis of multiple sclerosis. Raised cerebrospinal fluid and serum levels of the nitric oxide metabolites nitrate and nitrite have been described in patients with multiple sclerosis. Cerebrospinal fluid and serum nitrate and nitrite were measured in patients with multiple sclerosis, inflammatory and non-inflammatory neurological diseases, and correlated with the albumin quotient, an index of blood-brain-barrier dysfunction. Patients undergoing diagnostic lumbar and vene puncture were prospectively recruited, clinical data were obtained from the hospital records, and the CSF and serum nitrate and nitrite levels were measured by the nitrate reductase and Griess reaction methods. Nitrate and nitrite, were raised in the CSF and serum of patients with multiple sclerosis and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P < 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively). CSF nitrate and nitrite levels correlated with the albumin quotient (n = 59, r = 0.42, P < 0.001). This study pro...Continue Reading

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Citations

Feb 16, 1999·Brain Pathology·K J SmithP A Felts
Nov 11, 2006·Neuroepidemiology·Tatjana PekmezovicJelena Kostic
Sep 26, 2007·Multiple Sclerosis : Clinical and Laboratory Research·K RejdakG Giovannoni
Feb 27, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Violaine K HarrisSaud A Sadiq
Apr 26, 2001·Multiple Sclerosis : Clinical and Laboratory Research·J DrulovićM Mostarica Stojokvić
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Marcus KochJacques De Keyser
May 26, 2020·Journal of Neural Transmission·José A G AgúndezFélix Javier Jiménez-Jiménez
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Oct 12, 1999·Multiple Sclerosis : Clinical and Laboratory Research·G GiovannoniE J Thompson
Feb 8, 2021·Journal of Neuroimmunology·Duygu Eryavuz OnmazAli Unlu
Feb 13, 2004·Biological Psychiatry·Thayne L SweetenChristopher J McDougle

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