Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease

Neurobiology of Disease
Jari KankaanpääAnne M Remes

Abstract

Lipoprotein oxidation may play an important role in the pathogenesis of Alzheimer's Disease (AD), and therefore, we investigated cerebrospinal fluid (CSF) antibodies to oxidized low-density lipoprotein (OxLDL) in patients with AD and other neurodegenerative dementias. IgM and IgG antibody titers to OxLDL were measured in 50 CSF samples and 11 plasma samples using chemiluminescent ELISA. All CSF samples contained IgG antibodies, and also most IgM, binding to OxLDL. CSF antibodies to OxLDL were not related to CSF protein or albumin concentrations or plasma antibodies to OxLDL. Competition immunoassay for specificity demonstrated that about 50% of the CSF IgG binding to OxLDL was inhibited by soluble OxLDL. CSF IgG antibodies to OxLDL were significantly increased in AD patients compared to controls and to patients with frontotemporal lobar degeneration. The role of these antibodies in CSF is unknown and further investigations are needed.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P S RoheimG L Vega
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Dec 20, 1996·The Journal of Biological Chemistry·A L BiereD J Selkoe
Mar 1, 1997·Journal of Neurochemistry·M M VerbeekW E Van Nostrand
Mar 4, 2000·Free Radical Biology & Medicine·S SchipplingU Beisiegel
Aug 18, 2000·Free Radical Biology & Medicine·S HörkköJ L Witztum
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·J M WardlawJ Starr
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·E TarkowskiK Blennow
Sep 17, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Johannes Hulthe
Dec 29, 2004·Journal of Clinical Immunology·Reng-Rong DaYufen Qin
Feb 22, 2005·Free Radical Biology & Medicine·Quan LiuGeorge Perry
May 18, 2005·Journal of Lipid Research·Christoph J BinderJoseph L Witztum
Nov 22, 2005·Lancet Neurology·Leila A ShobabHoward H Feldman
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rashid DeaneBerislav V Zlokovic
Sep 6, 2007·Annals of the New York Academy of Sciences·John A McIntyreSteven T DeKosky
May 31, 1930·The Journal of Experimental Medicine·J Freund

❮ Previous
Next ❯

Citations

Oct 30, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ruomei LiDmitri Svistounov
Jan 13, 2016·European Journal of Nutrition·Rafael LonghiDiogo Onofre Souza
Nov 4, 2015·Brain, Behavior, and Immunity·Fan SuZhijun Zhang
Apr 7, 2011·The International Journal of Neuropsychopharmacology·Christoph LaskeJanko Dietzsch
Oct 16, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Scott E CountsElliott J Mufson
Jan 10, 2019·International Journal of Food Sciences and Nutrition·Hui ChenGuowei Huang
Jan 6, 2010·Journal of Neurochemistry·Ian J MartinsRalph N Martins
Sep 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kazuki IdeKoji Kawakami
Nov 27, 2020·The Journal of Applied Laboratory Medicine·Bryant LimEleftherios P Diamandis
Feb 25, 2021·Cellular and Molecular Neurobiology·Ursula MuñozMari Cruz Sadaba

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.