Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier

Annals of Clinical and Translational Neurology
Nasrin AsgariTrevor Owens

Abstract

To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and the distribution and pathogenic impact was evaluated. A distinct distribution pattern of aquaporin-4-immunoglobulin G deposition was observed in the subarachnoid and subpial spaces where vessels penetrate the brain parenchyma, via a paravascular route with intraparenchymal perivascular deposition. Perivascular astrocyte-destructive lesions were associated with blood-borne horseradish peroxidase leakage indicating blood-brain barrier breakdown. The cerebrospinal fluid aquaporin-4-immunoglobulin G therefore distributes widely in brain to initiate astrocytopathy and blood-brain barrier breakdown.

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Citations

Oct 27, 2015·Frontiers in Immunology·Reza KhorooshiTrevor Owens
Mar 21, 2016·Brain, Behavior, and Immunity·Aravinthan Varatharaj, Ian Galea
Mar 18, 2017·Current Opinion in Neurology·Romain MarignierSandra Vukusic
Sep 28, 2016·Journal of Neurosurgical Anesthesiology·Frederick A ZeilerLawrence M Gillman
Sep 21, 2018·The Australian and New Zealand Journal of Psychiatry·Gerwyn MorrisMichael Berk
Oct 25, 2017·The Journal of Experimental Medicine·Axel MontagneBerislav V Zlokovic
Oct 4, 2018·Physiological Reviews·Melanie D SweeneyBerislav V Zlokovic
Jan 30, 2018·Nature Reviews. Neurology·Melanie D SweeneyBerislav V Zlokovic
Apr 30, 2017·Neurology. Neuroimmunology and Neuroinflammation·Nasrin AsgariBrian G Weinshenker
Jun 12, 2018·BioMed Research International·Brhane Teklebrhan AssefaBirhanetensay Masresha Altaye
Apr 19, 2018·Journal of Neuroinflammation·Marlene Thorsen MørchTrevor Owens

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