Cerebrospinal fluid biomarkers of central dopamine deficiency predict Parkinson's disease

Parkinsonism & Related Disorders
D S GoldsteinYehonatan Sharabi

Abstract

Consistent with nigrostriatal dopamine depletion, low cerebrospinal fluid (CSF) concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), the main neuronal metabolite of dopamine, characterize Parkinson's disease (PD) even in recently diagnosed patients. Whether low CSF levels of DOPAC or DOPA, the precursor of dopamine, identify pre-clinical PD in at-risk healthy individuals has been unknown. Participants in the intramural NINDS PDRisk study entered information about family history of PD, olfactory dysfunction, dream enactment behavior, and orthostatic hypotension at a protocol-specific website. After at least 3 risk factors were confirmed by on-site screening, 26 subjects had CSF sampled for levels of catechols and were followed for at least 3 years. Of 26 PDRisk subjects, 4 were diagnosed with PD (Pre-Clinical PD group); 22 risk-matched (mean 3.2 risk factors) subjects remained disease-free after a median of 3.7 years (No-PD group). The Pre-Clinical PD group had lower initial DOPA and DOPAC levels than did the No-PD group (p = 0.0302, p = 0.0190). All 3 subjects with both low DOPA (<2.63 pmol/mL) and low DOPAC (<1.22 pmol/mL) levels, based on optimum cut-off points using the minimum distance method, developed PD, whereas non...Continue Reading

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Citations

Dec 7, 2019·Journal of Neural Transmission·David S Goldstein
Sep 19, 2020·Annals of Clinical and Translational Neurology·David S GoldsteinYehonatan Sharabi
Sep 15, 2018·Frontiers in Neuroscience·Fatemeh N Emamzadeh, Andrei Surguchov
Aug 8, 2020·Frontiers in Neurology·Yannick VermeirenPeter P De Deyn
Feb 6, 2019·Nature Microbiology·Mireia Valles-ColomerJeroen Raes
Nov 4, 2020·Nutrients·Karolina Skonieczna-ŻydeckaWojciech Marlicz
Feb 6, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Michaela KaiserovaPetr Kanovsky
Mar 13, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Guillaume LamotteDavid S Goldstein
Mar 13, 2021·Nature Communications·Eleanor SinclairPerdita Barran
May 5, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas KremerBrit Mollenhauer
May 15, 2021·Biomarkers in Medicine·Lara CheslowScott A Waldman
Jul 27, 2021·Frontiers in Aging Neuroscience·Upasana GangulySasanka Chakrabarti
Sep 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yong RenJian Feng
Sep 11, 2021·The Journal of Pharmacology and Experimental Therapeutics·David S GoldsteinYehonatan Sharabi

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