PMID: 3769991Sep 1, 1986Paper

Cerebrospinal fluid C-reactive protein in meningitis: diagnostic value and pathophysiology

European Journal of Pediatrics
E BenGershômF de Zegher

Abstract

We examined the diagnostic value of C-reactive protein (CRP) in cerebrospinal fluid (CSF) on initial lumbar puncture in a prospective study including 126 patients (30 neonates, 96 infants and children) suspected of having meningitis. Twenty patients were considered to have bacterial and 25 were considered to have viral meningitis. In infants and children, a retrospectively chosen cut-off CRP titre of 4 (i.e. approximately equal to 0.4 mg/l CRP) had a sensitivity of 100% and a specificity of 94% for differentiating bacterial meningitis from both viral meningitis and normal. It was a more sensitive and selective test for differentiating bacterial from viral meningitis on initial CSF examination than was the CSF leucocyte count, glucose concentration or protein concentration. In neonates, no such cut-off CRP titre could be found, presumably due to the immaturity of the blood-CSF-barrier (B1-CSF-B) during the first weeks of life. In a parallel study including a non-selected group of 13 infants and children (4 without, 9 with bacterial meningitis), the serum/CSF CRP concentration ratios were determined and inserted in the individual B1-CSF-B diagrams according to Felgenhauer. The results were fully consistent with the hypothesis tha...Continue Reading

References

Dec 22, 1984·Lancet·F de ZegherG J Briggeman-Mol
Apr 1, 1983·Developmental Medicine and Child Neurology·A Statz, K Felgenhauer
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Citations

Apr 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B HoenP Canton
Aug 1, 1995·Clinical Biochemistry·M ParadowskiB Kubasiewicz-Ujma
Jul 1, 1997·The Pediatric Infectious Disease Journal·B Z GartyY L Danon
Mar 1, 1997·Journal of Clinical Pathology·A O OlukogaD Donaldson
Apr 1, 1991·Pathology·B YoungA W Cripps
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
May 28, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Alexander G ThompsonMartin R Turner
Dec 1, 1988·Annals of Tropical Paediatrics·L E CuevasG H Mughogho
Nov 18, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·L U GerdesP Wang
Dec 14, 1999·The Journal of Emergency Medicine·B Clyne, J S Olshaker

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