PMID: 3762967Nov 1, 1986Paper

Cerebrospinal fluid C9 in demyelinating disease

Neurology
D A CompstonA K Campbell

Abstract

We measured CSF and plasma concentrations of C9, IgG, and albumin in 91 patients with demyelination and 73 controls with other neurologic diseases. The C9 index was reduced and IgG index increased in patients with multiple sclerosis and those with isolated demyelinating lesions, irrespective of disease activity; abnormalities were less marked in patients with isolated lesions than in those with MS. Humoral mechanisms may not be responsible for initiating demyelination, but activation of the complement system could amplify tissue damage and account for some symptomatic recovery.

Citations

Jun 1, 1993·Brain Research. Molecular Brain Research·D L GordonD Adrian
Jun 1, 1994·Progress in Neurobiology·N J ScoldingD A Compston
Feb 1, 1989·Research in Immunology·H P Hartung, K Heininger
Apr 28, 2010·Brain : a Journal of Neurology·Gillian IngramBryan Paul Morgan
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·D A CompstonA K Campbell
Feb 23, 2012·Multiple Sclerosis : Clinical and Laboratory Research·G IngramB P Morgan
Sep 25, 1999·Journal of Neuroimmunology·J ChatawayA Compston
Oct 1, 1992·Journal of Neuroimmunology·H P HartungK V Toyka
Jan 1, 1991·Annals of the New York Academy of Sciences·D A Compston, N J Scolding
Nov 14, 1997·Mayo Clinic Proceedings·W E HogancampB G Weinshenker
Apr 23, 2010·Journal of Neuroimmunology·Gillian IngramB Paul Morgan
Dec 2, 2008·Clinical and Experimental Immunology·G IngramB P Morgan
Apr 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J Fretland
Jun 3, 2014·Acta Neuropathologica Communications·Gillian IngramB Paul Morgan
Jul 1, 1989·Neuropathology and Applied Neurobiology·D A CompstonB Jasani
Jul 18, 2015·Neurological Research·Hoiyda A Abdel RasolMargeret A Aziz
Nov 9, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Wioleta Milena ZelekB Paul Morgan
Jan 1, 1989·Autoimmunity·N ScoldingA Compston

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