PMID: 11920545Mar 29, 2002Paper

Cerebrospinal fluid concentrations of vincristine after bolus intravenous dosing: a surrogate marker of brain penetration

Cancer
Stewart J KellieSiebold S N de Graaf

Abstract

Vincristine (VCR) is used widely in oncology practice, and regular dosing is commonly associated with the development of sensorimotor or autonomic neuropathies. However, the incidence of VCR-related central nervous system (CNS) toxicity is comparatively low, suggesting that the blood-brain barrier may limit drug penetration into the brain parenchyma. This study determined whether measurable concentrations of VCR could be detected in the cerebrospinal fluid (CSF), as a surrogate marker of brain parenchyma penetration, after bolus intravenous injection in children without primary CNS pathology. The authors studied 17 pediatric patients ages 2.5-14.1 years (median, 6.8 years) with acute lymphoblastic leukemia or non-Hodgkin lymphoma without evidence of leptomeningeal disease. Patients received VCR 1.5 mg/m2 by intravenous bolus injection followed at varying intervals by lumbar puncture for scheduled intrathecal methotrexate administration under general anesthesia. Paired VCR concentrations in both plasma and CSF were measured in each patient simultaneously at times ranging from 8 minutes to 146 minutes after the VCR injection. Three patients were studied twice. The paired samples were stored at -40 degrees C until analysis using a...Continue Reading

References

Aug 1, 1976·Journal of Neurosurgery·J G RosenstockL Schut
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·A SinghM K Gumerlock
Jan 1, 1989·The American Journal of Pediatric Hematology/oncology·F M Balis, D G Poplack
Sep 1, 1966·The British Journal of Surgery·L P LassmanJ Gang
Sep 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M L SlevinT A Lister
Jan 1, 1980·Cancer Chemotherapy and Pharmacology·V S SethiD V Jackson
Dec 1, 1994·Clinical and Laboratory Haematology·K GhoshJ K Wood
Apr 1, 1995·Medical and Pediatric Oncology·S S de GraafD R Uges
Aug 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R GeyerJ L Finlay
May 1, 1993·Pediatric Neurosurgery·A GajjarL E Kun
May 5, 1999·Critical Reviews in Oncology/hematology·C E GiddingS S de Graaf

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Citations

Dec 4, 2008·Annals of Hematology·Yok-Lam KwongJoyce C W Chan
Dec 26, 2006·Cancer Chemotherapy and Pharmacology·Steve Y ChoFrank M Balis
Dec 2, 2008·Cancer Chemotherapy and Pharmacology·Lindsay B KilburnStacey L Berg
Aug 3, 2013·Current Treatment Options in Oncology·Patrick RothMichael Weller
Jun 16, 2005·Current Problems in Pediatric and Adolescent Health Care·Adam S Levy
Aug 17, 2002·Methods : a Companion to Methods in Enzymology·Jan PasschierAren van Waarde
Oct 11, 2005·Journal of the International Neuropsychological Society : JINS·Annemieke I BuizerAnjo J P Veerman
Oct 6, 2009·Journal of Pediatric Hematology/oncology·Bernadette HennipmanAnjo J P Veerman
Aug 25, 2006·Clinical Pharmacokinetics·Susannah MotlClinton F Stewart
Mar 20, 2010·CNS Drugs·Laura J Klesse, Daniel C Bowers
Nov 26, 2009·The American Journal of Forensic Medicine and Pathology·Adriana D'AddarioMiguel Angel Riudavets
Dec 23, 2014·Leukemia & Lymphoma·Line Groth-PedersenKjeld Schmiegelow
May 1, 2010·Expert Opinion on Pharmacotherapy·Matteo G CarrabbaAndrés J M Ferreri
Aug 11, 2010·Critical Reviews in Oncology/hematology·Fabio CanovaSavina Maria Luciana Aversa
May 19, 2009·Lancet Neurology·Patrick G Morris, Lauren E Abrey
Oct 14, 2005·Journal of the Peripheral Nervous System : JPNS·David BalayssacFrançois Coudore
Oct 6, 2005·Pediatric Blood & Cancer·James D Weisfeld-AdamsDermot M Murphy
Jun 17, 2016·Expert Review of Neurotherapeutics·Antonin DréanAhmed Idbaih
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L MuldoonEdward A Neuwelt
Dec 19, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa M DeAngelisUNKNOWN Radiation Therapy Oncology Group Study 93-10
Jan 10, 2008·Expert Review of Anticancer Therapy·M Kelly Nicholas
Apr 19, 2018·Journal of Pediatric Hematology/oncology·Daniel C MoreiraTimothy P Garrington
Nov 9, 2005·Expert Review of Neurotherapeutics·M Kelly NicholasSamir Bangalore
Dec 22, 2019·International Journal of Molecular Sciences·Eurydice AngeliGuilhem Bousquet
May 30, 2019·The AAPS Journal·Jean-Marie Nicolas, Elizabeth C M de Lange
Jun 20, 2019·Cancer Chemotherapy and Pharmacology·Marie Lindhard MadsenKaren Dybkær
Jul 29, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·T Leigh Spencer NoakesBrian J Nieman
Apr 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen van der PlasYin Ting Cheung

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