PMID: 16511805Mar 3, 2006Paper

Cerebrospinal fluid from a 10-year-old dog with a single seizure episode

Veterinary Clinical Pathology
Kurt ZimmermanRobert Duncan

Abstract

A cerebrospinal fluid sample collected from the cerebellomedullary cistern of a 10-year-old Shetland Sheepdog with a recent history of seizures was submitted for fluid analysis and cytologic examination. Key findings included a total nucleated cell count of 520/microL (reference interval 0-5 cells/microL), with a predominance of mononuclear cells, a protein concentration of 51.8 mg/dL (reference interval 0-35 mg/dL), and a glucose concentration of 44.7 mg/dL (reference interval 52-105 mg/dL). There was marked atypia of the mononuclear cells, with abundant eosinophilic cytoplasm, marked anisocytosis and anisokaryosis, occasional binucleated cells, mitotic figures, and rare erythrophagia. The cytologic interpretation was marked, monocytoid-rich, mixed cell pleocytosis with cellular atypia worrisome for neoplasia. In addition to histiocytic neoplasia, differentials included granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and granulomatous inflammation. The dog did not respond to anti-inflammatory and anticonvulsive therapy. At necropsy, a mass involving the meninges and subtending the neuropil of the right temporal lobe of the cerebrum was found. Histologically, the mass was composed of large, bizarre hist...Continue Reading

Citations

Jan 15, 2010·Veterinary Clinical Pathology·Erica Behling-KellyKaren M Young
Feb 5, 2009·Journal of Veterinary Internal Medicine·L TziporyW Vernau
Nov 17, 2009·The Journal of Veterinary Medical Science·Tetsuya IdeHiroyuki Nakayama
Feb 26, 2015·Journal of Veterinary Internal Medicine·C L MarianiE MacKillop
Feb 26, 2008·The Veterinary Journal·Roberta Di Terlizzi, Simon R Platt
Apr 30, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Shinji TamuraKazuyuki Uchida
May 13, 2014·Journal of Veterinary Internal Medicine·P J Dickinson
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tetsuya IdeHiroyuki Nakayama
Dec 17, 2015·The Journal of Veterinary Medical Science·Atigan ThongtharbHiroyuki Nakayama
Jan 11, 2020·Journal of Veterinary Internal Medicine·Izumi ToyodaPeter J Dickinson
Feb 18, 2016·Veterinary Clinical Pathology·Caroline CluzelCarolyn Gara-Boivin

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