Abstract
Psychiatric comorbidity is one of the key elements in chronic migraine (CM) management. Depression is particularly common in these patients, occurring in up to 85%. Preclinical studies have suggested that gamma-aminobutyric acid (GABA) levels may be decreased in animal models of depression. Also, clinical studies have reported low level in mood disorder patients for both plasma and cerebrospinal fluid (CSF) GABA. We hypothesized that low GABA levels in the brain might be related to the depression associated with CM. We studied 14 chronic migraine patients, with or without depression, compared to age-and sex-matched controls. CSF GABA levels were measured by HPLC. CSF GABA levels showed significant lower levels in depressed patients than those without depression. No difference was found when comparing patients versus controls. A GABA deficiency may be the underlying mechanism of depression in CM. Hence, preventive therapies modulating GABA neurotransmission could be used in CM associated with depression.
References
May 1, 1992·Headache·H KowaK Takahashi
May 15, 1989·Brain Research·R C DruganS M Paul
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·K G LloydG Bartholini
Oct 29, 1984·Brain Research·E AlborchC Estrada
Oct 1, 1980·Behavioral and Neural Biology·A D Sherman, F Petty
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Jancsàr, B E Leonard
Dec 1, 1984·The American Journal of Psychiatry·R H GernerD J Cohen
Apr 1, 1982·Journal of Neurochemistry·W Löscher, H H Frey
Jun 1, 1995·Biological Psychiatry·F PettyA J Rush
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·T DennisN Lavoie
Jan 1, 1994·Epilepsia·E A CavalheiroM G Naffah-Mazzacoratti
Sep 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F PettyA J Rush
Aug 18, 1995·Journal of Affective Disorders·F Petty
May 1, 1996·Neurology·N T MathewL C Sanin
Oct 1, 1996·Neurology·S D SilbersteinM Sliwinski
Oct 6, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A Fergus, K S Lee
Jan 1, 1997·Pharmacology & Therapeutics·J P KellyB E Leonard
Oct 13, 1998·Life Sciences·I S Shiah, L N Yatham
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·G NorthoffB Bogerts
Jul 11, 2001·Neurology·A QuattroneK Pardatscher
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Citations
Oct 2, 2013·Brain : a Journal of Neurology·Mark A LouterGisela M Terwindt
Oct 6, 2011·Gene·Prue N PlummerLyn R Griffiths
May 5, 2009·Biological Psychiatry·Alvaro L Garcia-GarciaRosa M Tordera
May 3, 2011·European Journal of Pain : EJP·Filippo BrighinaBrigida Fierro
Nov 4, 2015·Journal of Psychosomatic Research·M A LouterG M Terwindt
Sep 21, 2010·Cephalalgia : an International Journal of Headache·Mario F P PeresWilliam B Young
Feb 19, 2016·Cephalalgia : an International Journal of Headache·Robin M van DongenMichel D Ferrari
Jul 13, 2017·Headache·Elena García-MartínFélix Javier Jiménez-Jiménez
Jun 19, 2018·Cephalalgia : an International Journal of Headache·Nadine PelzerGisela M Terwindt
Dec 18, 2013·Electrophoresis·Mercedes CasadoRafael Artuch
Mar 12, 2020·Cell & Bioscience·Xianchao DuYu Deng
May 11, 2019·The Journal of Headache and Pain·Thomas DreslerUNKNOWN European Headache Federation School of Advanced Studies (EHF-SAS)
May 9, 2007·Neurochemical Research·M Zafer GörenBerna Terzioglu
May 8, 2021·Frontiers in Human Neuroscience·Claudia AltamuraGianluca Coppola