Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism

Annals of Neurology
Allison BrashearW B Dobyns

Abstract

Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism. RDP has been reported by our group in two apparently unrelated families. We now report analysis of cerebrospinal fluid metabolites of dopamine, norepinephrine, and serotonin for mild and severely affected individuals, known asymptomatic gene carriers, and at-risk individuals from both families with RDP. Levels of the dopamine metabolite homovanillic acid (HVA) were decreased in severely affected patients and in some asymptomatic gene carriers. HVA levels increased with treatment in some affected individuals, but this increase did not predict clinical response to carbidopa/levodopa. We suggest that a low HVA level is a biological marker with modest association to the diagnosis of RDP.

References

Jul 1, 1980·Annals of Neurology·W E SeifertI J Butler
Jul 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·A Ishikawa, T Miyatake
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H TohgiT Kikuchi
Dec 1, 1993·Neurology·W B DobynsX O Breakefield
Apr 1, 1997·Neurology·A BrashearW B Dobyns

❮ Previous
Next ❯

Citations

Aug 12, 1999·Annals of Neurology·P L KramerA Brashear
Nov 30, 1999·Annals of Neurology·S J AugoodD G Standaert
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A BrashearG D Hutchins
Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Gurutz LinazasoroAsier Lasa
Nov 26, 2009·Journal of Neurology·Marina SvetelVladimir S Kostić
Aug 8, 2001·Parkinsonism & Related Disorders·J Jankovic, R Tintner
Jul 10, 2003·Lancet Neurology·Patricia M de Carvalho Aguiar, Laurie J Ozelius
Feb 7, 2007·Brain : a Journal of Neurology·Allison BrashearLaurie J Ozelius
Aug 31, 2012·Neurology·Allison BrashearW Vaughn McCall
Apr 18, 2014·Lancet Neurology·Erin L HeinzenUNKNOWN ATP1A3 Working Group
Sep 30, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Angela DeutschländerKai Bötzel
Apr 14, 2016·Neuroscience and Biobehavioral Reviews·M SmitM A Tijssen
Mar 26, 2002·Brain : a Journal of Neurology·Andrea H Németh
Jun 6, 2003·Seminars in Pediatric Neurology·Ergun Y Uc, Robert L Rodnitzky
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jacek ZarembaAllison Brashear
Feb 22, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Elizabeth J Slow, Anthony E Lang
Oct 7, 2021·Disease Models & Mechanisms·Hannah W Y NgSteven J Clapcote

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Allison BrashearW B Dobyns
Movement Disorders : Official Journal of the Movement Disorder Society
Gurutz LinazasoroAsier Lasa
Neurology
W B DobynsX O Breakefield
© 2022 Meta ULC. All rights reserved