Cerebrospinal fluid human immunodeficiency virus viral load in patients with neurosyphilis.

Journal of Neurovirology
Sergio de AlmeidaRonald J Ellis

Abstract

Syphilis is a frequent coinfection with human immunodeficiency virus (HIV). Whereas systemic syphilis infection increases plasma HIV RNA levels (viral load; VL), effects of syphilis on cerebrospinal fluid (CSF) VL are unknown. We hypothesized that intrathecal immune activation in neurosyphilis would selectively increase CSF VL in coinfected patients. In this study, HIV-infected research subjects (N = 225) were categorized into three groups based on serum rapid plasma reagin (RPR), microhemaglutination for Treponema pallidum (MHA-TP) MHA-TP, and CSF VDRL: 23 with neurosyphilis (NS+; reactive serum RPR and MHA-TP and positive CSF VDRL); 42 with systemic syphilis but not neurosyphilis (Syph+; reactive serum RPR and MHA-TP; negative CSF VDRL), and 160 without syphilis (Syph-; nonreactive serum RPR). Plasma and CSF HIV VL were quantified by reverse transcriptase-ploymerase chain reaction (RT-PCR) (Amplicor, Roche) in log(10) copies/ml. To adjust for covariates previously shown to influence CSF HIV VL (i.e., plasma VL, CD4, pleocytosis, and highly active antiretroviral therapy [HAART]), multivariable linear regression was used. Lumbar punctures (LP) done for research purposes diagnosed 23 with neurosyphilis; most (83%) of these repor...Continue Reading

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Citations

Dec 14, 2011·The Journal of Antimicrobial Chemotherapy·Aylin YilmazMagnus Gisslén
Dec 3, 2011·The Journal of Clinical Investigation·Emily L Ho, Sheila A Lukehart
Feb 5, 2013·Infection·B Mora-PerisA Winston
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Dec 4, 2019·AIDS·Andrea MastrangeloPaola Cinque
Apr 22, 2015·Sexual Health·Emily L Ho, Serena S Spudich
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Dec 6, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Alex Maurício Garcia SantosPaulo Sérgio Ramos de Araújo

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