Cerebrospinal Fluid Hyaluronan and Neurofibromatosis Type 2

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
Prasanth S AriyannurAshok B Pillai

Abstract

Neurofibromatosis type 2 (NF-2) is associated with mainly three types of recurrent benign tumors restricted to the central nervous system: schwannoma, meningioma and ependymoma. The absence of the protein NF2/Merlin causes an uninterrupted cell proliferation cascade originating from an abnormal interaction between an extracellular mucopolysaccharide, hyaluronan (HA), and schwann cell surface CD44 receptor, which has been identified as one of the central causative factors for schwannoma. Most tumors in NF-2 have a predilection to originate from either arachnoid cap cells or schwann cells of the cisternal portion of nerve rootlets that share a continuous exposure to cerebrospinal fluid (CSF). We hypothesize that the CSF HA may play a role in tumorigenesis in NF-2. In a prospective analysis over a period of one year, the levels of medium to low molecular weight HA (LMW HA) was estimated in the CSF of three subjects with central schwannomas and compared against that of age-sex matched controls, using Cetyltrimethylammonium bromide coupled turbidimetric assay and found to be seventeen-fold higher in the schwannoma subjects compared to the controls. HA was observed to be actively secreted by cultured schwannoma cells isolated from tu...Continue Reading

References

Dec 1, 1980·Analytical Biochemistry·U B Laurent, A Tengblad
Nov 3, 1995·International Journal of Cancer. Journal International Du Cancer·S KoochekpourA Merzak
Dec 1, 1995·Journal of Neuro-oncology·L ShermanM Hofmann
Sep 1, 1996·Acta Neurologica Scandinavica·U B LaurentK Lilja
Apr 9, 2001·Seminars in Cell & Developmental Biology·B P Toole
Nov 22, 2001·The Journal of Biological Chemistry·Eva A TurleyLilly Y W Bourguignon
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Apr 23, 2003·The American Journal of Pathology·Jeanine A WardBryan P Toole
Mar 17, 2004·Journal of Cell Science·Valerie M Weaver, Penney Gilbert
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·D Gareth R EvansRichard Ramsden
Oct 6, 2005·Genes & Development·Andrea I McClatchey, Marco Giovannini
Mar 8, 2006·Human Mutation·Michael E Baser, UNKNOWN Contributors to the International NF2 Mutation Database
Nov 1, 2007·British Journal of Cancer·M Curto, A I McClatchey
Jun 24, 2009·Orphanet Journal of Rare Diseases·D Gareth R Evans
Mar 3, 2011·The FEBS Journal·Suniti MisraShibnath Ghatak
Apr 1, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Michael E BaserD Gareth R Evans
Aug 14, 2012·The Laryngoscope·Brian A NeffHirohito Kita
Oct 13, 2012·Nature Protocols·Rossukon KaewkhawJohn W Haycock
Mar 15, 2018·Drug Metabolism and Personalized Therapy·Reenu Anne JoyPrasanth S Ariyannur

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
dissection
size-exclusion column chromatography

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

© 2022 Meta ULC. All rights reserved