Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls

Neuroscience Letters
Frank M SchmidtPeter Schönknecht

Abstract

Impairment of sleep-wake cycles and circadian rhythm are found in human narcolepsy which is characterized by deficiency of hypocretin (hcrt) or its receptors. A disturbed electroencephalography (EEG) based vigilance regulation is also found in affective disorders such as major depressive disorder (MDD) and mania. For the first time, in the present study hcrt levels were investigated in patients with a manic episode and compared with age-matched patients with MDD and controls. 15 subjects were enrolled in the study after admission to hospital: 5 manic (mean YMRS 15.6+/-2.9) and 5 age-matched patients with MDD (mean HDRS 11.6+/-8.0), and 5 age-matched controls without any neurological or psychiatric disorder. Cerebrospinal fluid (CSF) hcrt levels were measured in all three groups using a fluorescence immunoassay (FIA). Mean hcrt-1 level in manic patients (77.3+/-20.7 pg/ml) did not differ significantly compared to patients with MDD (75.6+/-15.7 pg/ml MDD) or controls (74.9+/-19.3 pg/ml). Hcrt levels and severity of disease did not show a significant association. In the present study, for the first time hcrt-1 levels in manic patients were investigated but did not reveal significant differences neither compared to age-matched pati...Continue Reading

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Citations

Jan 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·Peter SchönknechtStefan Geyer
Mar 22, 2013·BMC Medicine·Yves DauvilliersSophie Bayard
Dec 24, 2013·Current Psychiatry Reports·Fabio PizzaGiuseppe Plazzi
Jul 16, 2011·Psychiatry Research·Frank Martin SchmidtPeter Schönknecht
Aug 10, 2020·Neuroscience and Biobehavioral Reviews·Sharafuddin KhairuddinLee Wei Lim
May 26, 2021·International Journal of Psychiatry in Clinical Practice·Ö F AkçaA Bilgiç

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