Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality.

Tuberculosis
Valerie A C M KoekenArjan van Laarhoven

Abstract

Inflammation contributes to the pathophysiology and high mortality of tuberculous meningitis. The IL-1β pathway has been implicated in immunopathology and could be a target for host-directed therapy. IL-1β was elevated in the cerebrospinal fluid (CSF) of 225 HIV-uninfected tuberculous meningitis patients in Indonesia compared to controls, but did not predict subsequent mortality, nor did IL-6 or IL-1Ra. Furthermore, genetic loci known to regulate IL1B gene expression did not predict mortality in 443 tuberculous meningitis patients, although two of these loci did predict CSF IL-1β concentrations. Collectively, these data argue against a role for IL-1β targeted host-directed therapy in tuberculous meningitis.

References

Apr 28, 2010·Journal of Neuroimmunology·Elizabeth FoxRaphaela Goldbach-Mansky
Sep 9, 2017·Nature Reviews. Neurology·Robert J WilkinsonUNKNOWN Tuberculous Meningitis International Research Consortium
Feb 6, 2018·The Lancet Infectious Diseases·Arjan van LaarhovenReinout van Crevel
Jun 17, 2020·Wellcome Open Research·Ursula K RohlwinkUNKNOWN Tuberculous Meningitis International Research Consortium

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Citations

Mar 5, 2021·Current Opinion in Neurology·Sofiati DianArjan van Laarhoven

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