Cerebrospinal fluid IL-6, HSP72, and TNF-alpha in exercising humans

Brain, Behavior, and Immunity
Adam SteensbergBente Klarlund Pedersen

Abstract

During exercise the concentration of interleukin (IL)-6 and of heat shock protein (HSP) 72 increases in plasma, especially in fasting subjects. Both IL-6 and HSP72 are involved in a variety of metabolic and immunological processes, including some within the central nervous system and, accordingly, they are present not only in plasma but also in the cerebrospinal fluid (CSF). To evaluate whether, the two pools equilibrate we determined the levels of IL-6 and HSP72 in CSF, at a time when their plasma levels were increased due to exercise. Measurements of TNF-alpha served as a control, as its plasma level remains stable during exercise. Two groups of healthy, fit males performed 2 h of strenuous exercise with either carbohydrate ingestion (n=8) or placebo (n=8). The concentration of IL-6, HSP72, and TNF-alpha was measured in arterial blood and in the CSF obtained by a lumbar puncture immediately after exercise. A third group of subjects served as resting controls (n=8). At rest, CSF levels of IL-6 and HSP72 were 2- and 3-fold higher than the plasma levels, respectively (P<.05). During exercise, with and without carbohydrate ingestion, plasma IL-6 increased 8- and 18-fold, respectively, and HSP72 increased 5-fold (P<.05). However, ...Continue Reading

References

Sep 26, 1994·Neuroscience Letters·W A BanksE G Gutierrez
Jan 1, 1994·Neuroimmunomodulation·S M McCannV Rettori
Jul 1, 1995·Neuroimmunomodulation·W A BanksR D Broadwell
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Aug 3, 2002·The Journal of Physiology·Lars NyboNiels H Secher
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark A Febbraio, Bente Klarlund Pedersen
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay CampisiMonika Fleshner
Nov 2, 2002·The Journal of Physiology·Mark A FebbraioBente Klarlund Pedersen
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Gerrit van HallBente K Pedersen
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Kaj StenlöfJohn-Olov Jansson
Aug 20, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Paula J Robson-AnsleyTimothy D Noakes
Nov 17, 2004·Cell Stress & Chaperones·G I LancasterL Nybo
Oct 1, 2005·International Journal of Sports Medicine·E FehrenbachF C Mooren

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Citations

Dec 7, 2010·Cell Stress & Chaperones·Matthew B Fortes, Martin Whitham
Dec 7, 2011·Cell Stress & Chaperones·Kishiko OgawaStuart K Calderwood
Jun 19, 2013·Lancet Neurology·Giselle M PetzingerMichael W Jakowec
Jul 16, 2008·The Journal of Experimental Medicine·Maria BjörkqvistSarah J Tabrizi
Jan 4, 2008·Acta Physiologica·S Glund, A Krook
Nov 22, 2011·Veterinary Immunology and Immunopathology·Sarah A MooreMichael J Oglesbee
Nov 30, 2006·Brain, Behavior, and Immunity·Guillermo M AlexanderRobert J Schwartzman
Apr 5, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B Kayser, S Verges
Aug 24, 2010·The European Journal of Neuroscience·Pedro AlvarezPaul G Green
Jun 26, 2012·Journal of Pineal Research·José L MaurizJavier González-Gallego
Oct 31, 2006·The American Journal of Medicine·Richard Ruffin, Paul D Thompson
Apr 19, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Łukasz ZadkaMarcin Olajossy
Mar 19, 2013·International Journal of Molecular Sciences·Pengyue ZhangYongshan Hu
Jul 8, 2010·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Ricardo A PinhoFelipe Dal-Pizzol
Jul 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bjørn QuistorffJohannes J Van Lieshout
Oct 27, 2007·Journal of Applied Physiology·Neils H SecherJohannes J Van Lieshout
Nov 12, 2019·Frontiers in Molecular Neuroscience·Thulani H PalpagamaAndrea Kwakowsky

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