Cerebrospinal fluid in COVID-19 neurological complications: no cytokine storm or neuroinflammation.

MedRxiv : the Preprint Server for Health Sciences
Maria A GarciaCarlos A Pardo

Abstract

Neurological complications occur in COVID-19. We aimed to examine cerebrospinal fluid (CSF) of COVID-19 subjects with neurological complications and determine presence of neuroinflammatory changes implicated in pathogenesis. Cross-sectional study of CSF neuroinflammatory profiles from 18 COVID-19 subjects with neurological complications categorized by diagnosis (stroke, encephalopathy, headache) and illness severity (critical, severe, moderate, mild). COVID-19 CSF was compared with CSF from healthy, infectious and neuroinflammatory disorders and stroke controls (n=82). Cytokines (IL-6, TNFα, IFNγ, IL-10, IL-12p70, IL-17A), inflammation and coagulation markers (high-sensitivity-C Reactive Protein [hsCRP], ferritin, fibrinogen, D-dimer, Factor VIII) and neurofilament light chain (NF-L), were quantified. SARS-CoV2 RNA and SARS-CoV2 IgG and IgA antibodies in CSF were tested with RT-PCR and ELISA. CSF from COVID-19 subjects showed a paucity of neuroinflammatory changes, absence of pleocytosis or specific increases in pro-inflammatory markers or cytokines (IL-6, ferritin, or D-dimer). Anti-SARS-CoV2 antibodies in CSF of COVID-19 subjects (77%) were observed despite no evidence of SARS-CoV2 viral RNA. A similar increase of pro-inflamm...Continue Reading

Citations

Feb 21, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zahra BahariGholam Hossein Meftahi
Apr 4, 2021·International Journal of Molecular Sciences·Michelle A EricksonWilliam A Banks
May 12, 2021·Journal of Neurology·Rebecca De LorenzoRoberto Furlan
May 28, 2021·Frontiers in Immunology·Shahrzad ShorakaAmir Ghaemi
Aug 22, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·J J MerinoM P González

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Methods Mentioned

BETA
nucleic acid amplification
PCR
sedation
ELISA
Assay

Software Mentioned

REDCap

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