Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study

Infectious Diseases
Kristian BuchDanish Study Group for Infections in the Brain

Abstract

The ability of cerebrospinal fluid (CSF) lactate to distinguish between acute bacterial meningitis (ABM) and aseptic meningitis/encephalitis (AME) is debated. We assessed the diagnostic value of CSF lactate to discriminate between ABM and AME. We included 176 patients from a prospective adult cohort with neuroinfections. In total, 51 ABM and 125 AME patients with clinically and/or microbiologically diagnosed acute meningitis were examined with CSF-lactate and traditional markers for infection. Receiver operating characteristic (ROC) curves were used to assess diagnostic performance. In CSF, lactate, leukocytes, fraction of neutrophils, protein and glucose ratio, were significantly different between the ABM and AME groups. CSF lactate had the best diagnostic value, with an area under the curve (AUC) of 0.976 (95%CI 0.966-0.997) and using a cut-off of 3.5 mmol/L a sensitivity of 96% and specificity of 85%. Antibiotic treatment before lumbar puncture had no significant effect on the AUC of CSF lactate. Compared to traditional CSF-markers, CSF lactate is more accurate to distinguish between ABM and AME.

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Citations

Mar 21, 2020·Journal of Intensive Care Medicine·Tolga DittrichRaoul Sutter
Apr 10, 2020·Biomarkers in Medicine·Victoria PoplinNathan C Bahr
May 15, 2020·Practical Neurology·Aravindhan BaheerathanNicholas Ws Davies
Apr 25, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Renan Barros DominguesCarlos Senne
Jan 5, 2021·Archives of Virology·Amira KohilHadi M Yassine

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