Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity

PloS One
Diego M MoralesDavid D Limbrick

Abstract

Neurological outcomes of preterm infants with post-hemorrhagic hydrocephalus (PHH) remain among the worst in infancy, yet there remain few instruments to inform the treatment of PHH. We previously observed PHH-associated elevations in cerebrospinal fluid (CSF) amyloid precursor protein (APP), neural cell adhesion molecule-L1 (L1CAM), neural cell adhesion molecule-1 (NCAM-1), and other protein mediators of neurodevelopment. The objective of this study was to examine the association of CSF APP, L1CAM, and NCAM-1 with ventricular size as an early step toward developing CSF markers of PHH. CSF levels of APP, L1CAM, NCAM-1, and total protein (TP) were measured in 12 preterm infants undergoing PHH treatment. Ventricular size was determined using cranial ultrasounds. The relationships between CSF APP, L1CAM, and NCAM-1, occipitofrontal circumference (OFC), volume of CSF removed, and ventricular size were examined using correlation and regression analyses. CSF levels of APP, L1CAM, and NCAM-1 but not TP paralleled treatment-related changes in ventricular size. CSF APP demonstrated the strongest association with ventricular size, estimated by frontal-occipital horn ratio (FOR) (Pearson R = 0.76, p = 0.004), followed by NCAM-1 (R = 0.66,...Continue Reading

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Citations

Sep 9, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Rowland H HanDavid D Limbrick
Feb 18, 2017·PloS One·David D LimbrickDiego M Morales
Feb 18, 2020·Cell and Tissue Research·Roberto HenziMontserrat Guerra

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Methods Mentioned

BETA
immunodepletion
PMA
Enzyme-Linked ImmunoSorbent Assays
ELISA
protein assay

Software Mentioned

CRIB

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