PMID: 15222688Jun 30, 2004Paper

Cerebrospinal fluid levels of brain specific proteins in optic neuritis

Multiple Sclerosis : Clinical and Laboratory Research
E T LimG Giovannoni

Abstract

This study evaluates levels of cerebrospinal fluid (CSF) brain-specific proteins (BSP) in subjects with optic neuritis (ON) who are at high risk of progression to multiple sclerosis (MS). Forty-one subjects had acute ON and 17 subjects with other neurological diseases (OND) served as controls. Twenty-one subjects with ON had white matter lesions on magnetic resonance imaging (MRI) and intrathecal synthesis of oligoclonal IgG bands (OB) consistent with being at high risk of progression to MS; eight of whom later were diagnosed with clinically definite MS (CDMS). Levels of S100B, ferritin and two neurofilament heavy chain phosphoforms (NfH(SM134) and NfH(SM135)) were analysed using ELISA technique. A putative index of 'axonal health' was expressed as a ratio of NfH(SM134) to NfH(S135). NfH(SM134) and the NfH(SM134:SM135) were significantly elevated in subjects with ON compared to controls. No significant differences in levels of CSF BSP were seen between ON subjects with CDMS plus those at high risk of progression to MS and ON subjects with normal MRI and negative CSF analysis. In conclusion, there is evidence of axonal damage in subjects who present with ON, which is independent of the diagnosis of CDMS.

References

Sep 1, 1990·Annals of Clinical Biochemistry·G KeirE J Thompson
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·D A FrancisW I McDonald
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M E GoldsteinN H Sternberger
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jul 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·G KeirE J Thompson
Jun 1, 1996·Glia·J R Connor, S L Menzies
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
Jun 23, 1997·Journal of Immunological Methods·A J GreenE J Thompson
Jul 30, 1999·Journal of the Neurological Sciences·S W HuletJ R Connor
Aug 28, 1999·Journal of the Neurological Sciences·P A BrexD H Miller
Jan 18, 2002·The New England Journal of Medicine·Peter A BrexDavid H Miller
Dec 21, 2002·Lancet·S J HickmanG T Plant
Sep 6, 2003·Journal of Immunological Methods·A PetzoldE J Thompson

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Citations

Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·E T LimG Giovannoni
Jul 5, 2008·Expert Review of Molecular Diagnostics·Hayrettin TumaniJohannes Brettschneider
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F DeisenhammerUNKNOWN EFSN
Nov 19, 2011·Multiple Sclerosis International·Irena Dujmovic
Jun 1, 2007·Biomarkers in Medicine·Charlotte E TeunissenGavin Giovannoni
Aug 29, 2009·Molecular Diagnosis & Therapy·Violaine K Harris, Saud A Sadiq
May 26, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Nicolas DubuissonSharmilee Gnanapavan
Nov 19, 2011·Multiple Sclerosis International·Michael KhalilChristian Langkammer
Oct 25, 2013·Expert Review of Molecular Diagnostics·Kina Höglund, Hugh Salter
Sep 26, 2007·Multiple Sclerosis : Clinical and Laboratory Research·K RejdakG Giovannoni
Apr 23, 2021·The Clinical Journal of Pain·Xin YangChangsheng Huang

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