Cerebrospinal fluid markers in Creutzfeldt-Jakob disease.

Cerebrospinal Fluid Research
Anders SkinningsrudTormod Fladby

Abstract

The objective was to assess the utility of total tau protein (tTau), the ratio of (tTau)/181 phosphorylated tau protein (P-Tau) and 14-3-3 protein, as diagnostic markers in cerebrospinal fluid (CSF) for Creutzfeldt-Jakob disease (CJD). CSF samples received from Norwegian hospitals between August 2005 and August 2007 were retrospectively selected from consecutive patients with tTau values > 1200 ng/L (n = 38). The samples from patients clinically diagnosed with CJD (n = 12) were compared to those from patients with other degenerative neurological diseases: Alzheimer's/vascular dementia (AD/VaD, n = 21), other neurological diseases (OND, n = 5). Total Tau, P-Tau, and beta-Amyloid (Abeta42) were measured with commercial kits. Additionally, 14-3-3 protein was measured semi-quantitatively by immunoblot. The minimum cut-off limits for diagnosis of CJD were chosen from the test results. For tTau the lower limit was fixed at 3000 ng/L, for the tTau/P-Tau ratio it was 60, and for 14-3-3 protein it was 0.75 arbitrary units. For tTau and tTau/P-Tau ratio, all but three CJD patients had levels above the minimum, whereas almost all of the other patients were below. For the 14-3-3 protein, two CJD patients were below the minimum and five wer...Continue Reading

References

Jun 26, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·B Van EverbroeckP Cras
Sep 6, 2003·The Veterinary Record·S L BenestadB Bratberg
Jul 28, 2004·Neurology·M RiemenschneiderA Kurz
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J Collinge

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Citations

Nov 13, 2008·Acta Neuropathologica·Roy O WellerRoxana O Carare
Feb 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Argonde C van HartenPhilip Scheltens
Jul 1, 2011·Expert Opinion on Medical Diagnostics·Isabelle QuadrioGabor G Kovacs
Jan 26, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O S CohenJ Chapman
Dec 3, 2014·Journal of Neurology·Oren S CohenDalia Shechter-Amir
Dec 10, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O S CohenJ Chapman
Aug 29, 2009·Molecular Diagnosis & Therapy·Violaine K Harris, Saud A Sadiq
May 1, 2021·Viruses·Mark P Figgie, Brian S Appleby

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Methods Mentioned

BETA
biopsy
enzyme linked immunosorbent assay
ELISA

Software Mentioned

Fujifilm Multi Gauge
Analyse
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