Abstract
The objective was to assess the utility of total tau protein (tTau), the ratio of (tTau)/181 phosphorylated tau protein (P-Tau) and 14-3-3 protein, as diagnostic markers in cerebrospinal fluid (CSF) for Creutzfeldt-Jakob disease (CJD). CSF samples received from Norwegian hospitals between August 2005 and August 2007 were retrospectively selected from consecutive patients with tTau values > 1200 ng/L (n = 38). The samples from patients clinically diagnosed with CJD (n = 12) were compared to those from patients with other degenerative neurological diseases: Alzheimer's/vascular dementia (AD/VaD, n = 21), other neurological diseases (OND, n = 5). Total Tau, P-Tau, and beta-Amyloid (Abeta42) were measured with commercial kits. Additionally, 14-3-3 protein was measured semi-quantitatively by immunoblot. The minimum cut-off limits for diagnosis of CJD were chosen from the test results. For tTau the lower limit was fixed at 3000 ng/L, for the tTau/P-Tau ratio it was 60, and for 14-3-3 protein it was 0.75 arbitrary units. For tTau and tTau/P-Tau ratio, all but three CJD patients had levels above the minimum, whereas almost all of the other patients were below. For the 14-3-3 protein, two CJD patients were below the minimum and five wer...Continue Reading
References
Apr 11, 1997·Neuroscience Letters·M OttoS Poser
Apr 12, 2002·FEBS Letters·Kenneth B RankSatish K Sharma
Jun 26, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·B Van EverbroeckP Cras
Feb 26, 2003·Neurology·D StrozykL J Launer
Mar 28, 2003·Molecular Psychiatry·M RiemenschneiderA Kurz
Sep 6, 2003·The Veterinary Record·S L BenestadB Bratberg
Jul 28, 2004·Neurology·M RiemenschneiderA Kurz
May 11, 2005·Neurology·A LadoganaI Zerr
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J Collinge
Nov 22, 2005·Neurobiology of Aging·Katharina BuergerHarald Hampel
Apr 25, 2006·Cellular and Molecular Neurobiology·Katsuya SatohHidenori Matsuo
Aug 23, 2006·Neurology·P Sanchez-JuanI Zerr
Sep 13, 2006·Neurology·V StensetT Fladby
Citations
Nov 13, 2008·Acta Neuropathologica·Roy O WellerRoxana O Carare
Aug 21, 2010·Journal of Neurology·Oren S CohenIsak Prohovnik
Aug 15, 2009·AIDS Research and Human Retroviruses·Carolina AlbertiMaria Valenzuela
Oct 29, 2011·BMC Neurology·Michael B CoulthartNeil R Cashman
Mar 17, 2011·PloS One·Ajay SinghNeena Singh
Feb 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Argonde C van HartenPhilip Scheltens
Jul 1, 2011·Expert Opinion on Medical Diagnostics·Isabelle QuadrioGabor G Kovacs
Jan 26, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O S CohenJ Chapman
Aug 12, 2009·Experimental Neurology·Giulia M SancesarioGiuseppe Sancesario
Jun 15, 2011·Journal of Neuroscience Research·Horacio MaldonadoMaría A Valenzuela
Dec 3, 2014·Journal of Neurology·Oren S CohenDalia Shechter-Amir
May 5, 2012·Upsala Journal of Medical Sciences·Jacek JaworskiHalina Bartosik-Psujek
Sep 26, 2016·Molecular Neurobiology·Silvia KoscovaEva Mitrova
Mar 28, 2013·Biomarker Insights·Chera L MaaroufUNKNOWN Arizona Parkinson’s Disease Consortium
Jul 16, 2019·Prion·Sol Moe LeeSu Yeon Kim
Dec 10, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O S CohenJ Chapman
Aug 29, 2009·Molecular Diagnosis & Therapy·Violaine K Harris, Saud A Sadiq
Nov 24, 2016·BMC Neurology·Edgaras DirziusKestutis Petrikonis
May 1, 2021·Viruses·Mark P Figgie, Brian S Appleby
Jun 2, 2021·The Journal of Applied Laboratory Medicine·Heidi StrandMorten K Moe