Cerebrospinal fluid pressure and prolactin in empty sella syndrome

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Giulio MairaA Barbarino

Abstract

In 58 female patients with the primary empty sella (PES) syndrome, a study of the CSF dynamics was done by evaluating both the absorptive reserve by a lumbar infusion test at constant rate, and/or the ICP increase occurring during REM phase of nocturnal physiological sleep. In 33, prolactin (PRL) dynamics were also investigated evaluating both the response to sequential stimulating test with thyrotropin-releasing hormone (TRH) and metoclopramide (MCP) and/or the circadian variation of PRL levels. Impairment of CSF dynamics was found in the 84% who had a hormonal pattern characterized by an increase of the PRL response to TRH and MCP and a decrease of the PRL circadian variation. Twenty-one patients with impaired CSF dynamics underwent CSF shunting procedures with disappearance of the signs of intracranial hypertension. They also had restoration of normal PRL dynamics but the endocrine alterations improved only moderately. Altered CSF dynamics play a role in the pathogenesis of the PES syndrome. A correlation between elevated ICP and the hypothalamo-hypophyseal control of PRL secretion may exist.

References

Jun 1, 1975·Neurology·K M Foley, J B Posner
Aug 1, 1975·Journal of Neurosurgery·L A WeisbergD P Saur
May 1, 1974·The Journal of Pharmacy and Pharmacology·P HuntJ Raynaud
Mar 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·A H KayeJ King

❮ Previous
Next ❯

Citations

Feb 8, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rodney J Schlosser, William E Bolger
Oct 29, 2003·Neurological Research·Annunziato MangiolaGiulio Maria
Mar 9, 2010·Journal of Endocrinological Investigation·A GiustinaE degli Uberti
Aug 12, 2006·The Annals of Otology, Rhinology, and Laryngology·Rodney J SchlosserWilliam E Bolger
Apr 22, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rodney J SchlosserWilliam E Bolger
Jan 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Sarah K Wise, Rodney J Schlosser
Aug 7, 2017·European Journal of Endocrinology·S ChiloiroL De Marinis
Jul 28, 2016·American Journal of Rhinology & Allergy·Raewynn G CampbellJames N Palmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.