PMID: 2116086Aug 1, 1990Paper

Cerebrospinal fluid prostaglandins, interleukin 1 beta, and tumor necrosis factor in bacterial meningitis. Clinical and laboratory correlations in placebo-treated and dexamethasone-treated patients

American Journal of Diseases of Children
M M MustafaG H McCracken

Abstract

Prostaglandins (PGs), interleukin 1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF alpha) are likely mediators of local inflammatory reactions. We measured PGE2, PGI2, IL-1 beta, and TNF concentrations in paired cerebrospinal fluid (CSF) samples (on admission, CSF1, and 18 to 30 hours later, CSF2) from 80 infants and children with bacterial meningitis. Forty patients received dexamethasone sodium (0.6 mg/kg per day in four intravenous doses) and 40 received an intravenous saline placebo. In CSF1, PGE2, PGI2, IL-1 beta, and TNF were detected in 90%, 56%, 98%, and 71% of specimens with mean (+/- SEM) concentrations of 462 +/- 65, 377 +/- 62, 1266 +/- 242, and 799 +/- 227 pg/mL, respectively. Concentrations of PGE2 correlated significantly with PGI2, IL-1 beta, TNF, and lactate and inversely correlated with glucose concentrations in the first CSF specimens. The PGE2, PGI2, IL-1 beta, and TNF were still detected in 40%, 18%, 97%, and 60%, respectively, of second CSF specimens obtained from placebo-treated patients. Compared with patients who had detectable PGI2 or TNF alpha concentrations in CSF2 specimens, those placebo-treated patients with no detectable PGI2 or TNF alpha activity in CSF2 had a lower incidence of neurolog...Continue Reading

Citations

Mar 1, 1994·Italian Journal of Neurological Sciences·A R MassaroL Callegaro
Apr 1, 1993·Postgraduate Medical Journal·B L PriestleyA Gibson
Jul 1, 1996·The Pediatric Infectious Disease Journal·T SlusherG H McCracken
Oct 16, 1999·The Laryngoscope·M G DeSautel, H A Brodie
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Norman N GeHilary A Brodie
Feb 1, 1994·Pediatric Annals·H S Jafari, G H McCracken
Nov 1, 1995·Parasitology·A L Neill, N H Hunt
Nov 5, 2016·The Cochrane Database of Systematic Reviews·Ian K Maconochie, Soumyadeep Bhaumik
Feb 1, 1995·European Journal of Pediatrics·R F KornelisseH J Neijens
Jun 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K TullusA Brauner
Dec 29, 2000·Molecular Psychiatry·L VitkovicC Jacque
Aug 19, 2010·The Laryngoscope·Lise WorsøePer Cayé-Thomasen
May 25, 2012·Neuroscience Bulletin·Hong-Mei YuBi-Wen Peng
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Tinuade A OgunlesiOlufemi T Oladapo
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·A Lauritsen, B Oberg
Nov 30, 2000·Current Treatment Options in Neurology·K L Roos
Jan 22, 2000·The Pediatric Infectious Disease Journal·I C MichelowJ M Pettifor
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petra J G ZwijnenburgA Marceline Van Furth
Nov 30, 2006·Clinical Science·Jan P KonsmanAnne-Marie Van Dam
Feb 12, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Lise WorsøePer Cayé-Thomasen
Aug 25, 2016·Frontiers in Human Neuroscience·Lianne HoeijmakersAniko Korosi
Mar 27, 2021·Current Opinion in Neurology·Emma C WallRobert S Heyderman
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld
Jan 1, 1991·International Journal of Antimicrobial Agents·A R Tunkel, W Michael Scheld
Jun 27, 2003·Lancet·Xavier Sáez-Llorens, George H McCracken
Oct 1, 1993·Annals of Emergency Medicine·J D Lipton, R W Schafermeyer
Oct 1, 1993·Annals of Emergency Medicine·J D Lipton, R W Schafermeyer
Mar 6, 2003·Neurologic Clinics·Daniel J Bonthius, Bahri Karacay
Jun 1, 1995·The Journal of Pediatrics·S J DulkerianM C Harris

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