Cerebrospinal fluid reference ranges in term and preterm infants in the neonatal intensive care unit.

The Journal of Pediatrics
Lakshmi SrinivasanMary C Harris

Abstract

To determine reference ranges of cerebrospinal fluid (CSF) laboratory findings in term and preterm infants in the neonatal intensive care unit. Data were collected prospectively as part of a multisite study of infants aged <6 months undergoing lumbar puncture for evaluation of suspected sepsis. Infants with a red blood cell count >500 cells/μL or a known cause of CSF pleocytosis were excluded from the analysis. A total of 318 infants met the inclusion criteria. Of these, 148 infants (47%) were preterm, and 229 (72%) received antibiotics before undergoing lumbar puncture. The upper reference limit of the CSF white blood cell (WBC) count was 12 cells/μL in preterm infants and 14 cells/μL in term infants. CSF protein levels were significantly higher in preterm infants (upper reference limit, 209 mg/dL vs 159 mg/dL in term infants; P < .001), and declined with advancing postnatal age in both groups (preterm, P = .008; term, P < .001). CSF glucose levels did not differ in term and preterm infants. Antibiotic exposure did not significantly affect CSF WBC, protein, or glucose values. CSF WBC counts are not significantly different in preterm and term infants. CSF protein levels are higher and decline more slowly with postnatal age in p...Continue Reading

References

Jul 1, 1992·The Pediatric Infectious Disease Journal·W A BonadioD Smith
Apr 1, 1982·American Journal of Diseases of Children·L D PappuB Kaplan
Oct 1, 1998·Arquivos de neuro-psiquiatria·C M Nascimento-Carvalho, O A Moreno-Carvalho
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·J P StevensD Harvey
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Feb 23, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pia A JohanssonNorman R Saunders
May 1, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Maroun J MhannaHany F Aziz
Aug 30, 2008·American Journal of Perinatology·P Brian SmithDaniel K Benjamin
Jul 16, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Samir S ShahJoseph J Zorc
Aug 31, 2010·The Journal of Pediatrics·Carrie L ByingtonXiaoming Sheng

❮ Previous
Next ❯

Citations

Nov 28, 2012·Seminars in Perinatology·Lakshmi SrinivasanSamir S Shah
May 10, 2013·Critical Reviews in Clinical Laboratory Sciences·Julie L V ShawKhosrow Adeli
Nov 27, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·A R Bedford Russell, R Kumar
May 27, 2015·The Journal of Pediatrics·Matthew B Wallenstein, Courtney J Wusthoff
Jan 8, 2015·Frontiers in Neuroscience·Norman R SaundersHans-Christian Bauer
Aug 4, 2016·Pediatric Research·Lakshmi SrinivasanMary C Harris
May 25, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Luca BedettiAlberto Berardi
May 19, 2018·The Journal of Physiology·Norman R SaundersMark D Habgood
Feb 3, 2018·Orphanet Journal of Rare Diseases·Jennifer M KwonJoseph J Orsini
Apr 30, 2013·The Pediatric Infectious Disease Journal·Lakshmi SrinivasanMary C Harris
Jul 1, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Massimiliano CastellazziMaura Pugliatti
May 24, 2014·The Pediatric Infectious Disease Journal·Elena ParianiSandro Binda
Jun 18, 2019·The Pediatric Infectious Disease Journal·Hana Mijovic, Manish Sadarangani
Jul 4, 2017·Frontiers in Pediatrics·Scott M GordonMary Catherine Harris
Mar 16, 2018·Fluids and Barriers of the CNS·Mona NoureldeinMichael Eisenhut
Nov 30, 2020·Brain & Development·Daisuke TajimaMuneaki Matsuo
Oct 23, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Huixian LiHuiying Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.