Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease

Neurobiology of Aging
André KarchInga Zerr

Abstract

The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic marker for patient survival. However, subtype determination is not possible during lifetime. Because the rate of disease progression is associated with the molecular subtype, this study aimed at investigating if total tau, a marker of neuronal death, allows premortem diagnosis of molecular subtype when codon 129 genotype is known. Two hundred ninety-six sCJD patients were tested for their cerebrospinal fluid total tau level at the time of diagnosis and were investigated for their sCJD subtype postmortem. There was a significant association between tau levels and the prion protein type in patients with codon 129 MM (p < 0.001), MV (p = 0.004), and VV (p = 0.001) genotype. Receiver operating characteristic analyses showed values of area under the curve of 0.76-0.80 for the different genotypes indicating a good diagnostic validity of the test. Total tau can be used as a diagnostic test for the assessment of prion protein type when codon 129 genotype is known. It provides valuable information for physicians and next of kin about the further course of disease.

References

Sep 28, 2005·Human Genetics·Gábor G KovácsUNKNOWN EUROCJD
May 3, 2007·Brain : a Journal of Neurology·U HeinemannI Zerr
Jun 10, 2009·Neurology·B MeissnerI Zerr
Sep 24, 2009·Brain : a Journal of Neurology·I ZerrP Sanchez-Juan
Jun 20, 2012·Lancet Neurology·Gianfranco PuotiPierluigi Gambetti

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Citations

Apr 5, 2016·Annals of Clinical and Translational Neurology·Shorena JanelidzeOskar Hansson
Mar 27, 2016·Progress in Neurobiology·Franc LlorensInga Zerr
Apr 1, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K GmitterováI Zerr
Nov 29, 2016·Annals of Neurology·Aaron FoutzJiri G Safar
Oct 28, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Piotr LewczukUNKNOWN Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato
May 18, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Kaj BlennowFranc Llorens
Oct 1, 2017·Experimental and Therapeutic Medicine·Xingbang WangQun Zhang
Jul 3, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Franc LlorensInga Zerr
Nov 22, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Franc LlorensInga Zerr
Feb 21, 2021·Lancet Neurology·Peter HermannInga Zerr
Apr 22, 2021·Acta Neuropathologica·Daniela Diaz-LucenaFranc Llorens

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