PMID: 9527138Apr 4, 1998Paper

Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: a community based follow up study

Journal of Neurology, Neurosurgery, and Psychiatry
N AndreasenK Blennow

Abstract

Biochemical markers for Alzheimer's disease would be of great value, especially to help in diagnosis early in the course of the disease. A pronounced increase in CSF tau protein (CSF-tau) is found in most patients with Alzheimer's disease. However, the specificity has to be further studied, as an increase in CSF-tau has also been found in other dementias, especially in vascular dementia. As most previous CSF studies have been based on selected inpatients, it was considered of special interest to examine the diagnostic potential of CSF-tau in a community population based sample of consecutive patients with dementia. Such patient material has been examined at the Piteå River Valley Hospital in Northern Sweden since 1986, and includes all those with memory disturbances in the community. The aim was also to study if an increase in CSF-tau is found early in the disease process, and whether CSF-tau changes during the progression of disease. Community population based sample of 75 demented patients (43 with Alzheimer's disease, 21 with vascular dementia, and 11 with mixed Alzheimer's disease/vascular dementia), 18 healthy subjects, and 18 neurological controls. A follow up investigation (including analysis of a new CSF sample) was per...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1991·Alzheimer Disease and Associated Disorders·A Wallin, K Blennow
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Nov 1, 1987·Neurobiology of Aging·P D Coleman, D G Flood
May 7, 1983·British Medical Journal·D G AltmanS J Pocock
Nov 1, 1993·Trends in Neurosciences·M Goedert
Sep 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R E TatoA Hernanz
Jun 16, 1995·Neuroscience Letters·D Y HuangW J Strittmatter
May 1, 1995·Acta Neurologica Scandinavica·S Tarvonen-SchröderL Sourander
Feb 17, 1995·Neuroscience Letters·M JensenL Lannfelt
Sep 18, 1993·Lancet·J PoirierS Gauthier
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Feb 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·N RöslerK A Jellinger
Dec 1, 1995·Molecular and Chemical Neuropathology·K BlennowE Vanmechelen
Jan 1, 1996·Acta Neuropathologica·O KosunenP J Riekkinen
Jan 1, 1996·Acta Neuropathologica·K A Jellinger
Jul 19, 1996·Neuroscience Letters·M RiemenschneiderW G Guder
Dec 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·I SkoogK Blennow

❮ Previous
Next ❯

Citations

Sep 23, 2008·Molecular Diagnosis & Therapy·Anders Lönneborg
Aug 11, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Reiber
Feb 13, 2001·Clinical Biochemistry·E P DiamandisA R Soosaipillai
Oct 9, 2001·Mechanisms of Ageing and Development·A Wallin, M Sjögren
Apr 12, 2002·Progress in Neurobiology·François Torreilles, Jacques Touchon
Mar 5, 2003·Neuroscience Letters·Lars-Olov Wahlund, Kaj Blennow
Jul 19, 2008·Lancet Neurology·Joshua A SonnenThomas J Montine
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hideyuki HattoriHiroshi Yoshida
Nov 11, 2011·Current Opinion in Neurology·Oscar L LopezJames T Becker
May 13, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Georg JuckelUlrich Hegerl
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G WaldemarUNKNOWN EFNS
Sep 23, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C HaenseH Hampel
Jan 17, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G P ParaskevasD Vassilopoulos
Apr 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·M SjögrenK Blennow
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A J GreenR S Knight
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·E TarkowskiK Blennow
Feb 18, 2006·Dementia and Geriatric Cognitive Disorders·Johannes BrettschneiderHayrettin Tumani
May 10, 2006·Dementia and Geriatric Cognitive Disorders·Edward D HueyTrey Sunderland
Feb 22, 2012·Dementia and Geriatric Cognitive Disorders·John M RingmanGreg M Cole
May 31, 2011·Journal of Biomedical Science·Jasmine P DevadhasanJeongho An
Jun 5, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·H ReiberA Wormek
May 19, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Pierre R BurkhardIrmgard Irminger
Feb 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Argonde C van HartenPhilip Scheltens
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Kaj Blennow
Jun 1, 2006·Neuropsychiatric Disease and Treatment·Aoife HuntJohannes Schröder
Jan 24, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Gorana MandićVladimir Kostić
Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Sep 24, 2014·Pathologie-biologie·N El KadmiriA Soukri
Aug 21, 2015·Critical Reviews in Clinical Laboratory Sciences·Giulia M Sancesario, Sergio Bernardini
Nov 1, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Daniëlle de JongMarcel M Verbeek
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Nicolaas A VerweyMarinus A Blankenstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.