Cerebrospinal fluid vasopressin and symptom severity in children with autism

Annals of Neurology
Ozge OztanKaren J Parker

Abstract

Autism is a brain disorder characterized by social impairments. Progress in understanding autism has been hindered by difficulty in obtaining brain-relevant tissues (eg, cerebrospinal fluid [CSF]) by which to identify markers of disease and targets for treatment. Here, we overcome this barrier by providing evidence that mean CSF concentration of the "social" neuropeptide arginine vasopressin (AVP) is lower in children with autism versus controls. CSF AVP concentration also significantly differentiates individual cases from controls and is associated with greater social symptom severity in children with autism. These findings indicate that AVP may be a promising CSF marker of autism's social deficits. Ann Neurol 2018;84:611-615.

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Citations

May 3, 2019·Current Opinion in Neurology·Hidenori YamasueElizabeth Berry-Kravis
Jul 18, 2020·Autism Research : Official Journal of the International Society for Autism Research·Catherine F TalbotKaren J Parker
Apr 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ozge OztanKaren J Parker
Sep 12, 2020·Pharmacological Reviews·C Sue CarterMarcy A Kingsbury
May 30, 2020·Cellular and Molecular Neurobiology·Juliana BaranovaRicardo G Correa
Apr 14, 2021·Autism Research : Official Journal of the International Society for Autism Research·Adam K MyersKaren J Parker
Jun 24, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·James T McCrackenUNKNOWN ISCTM/ECNP ASD Working Group
Oct 15, 2021·Médecine sciences : M/S·Amélie M BorieFreddy Jeanneteau

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