Cerebrospinal fluid viral load and intrathecal immune activation in individuals infected with different HIV-1 genetic subtypes.

PloS One
Sahra AbdulleMagnus Gisslén

Abstract

HIV-1 exhibits a high degree of genetic diversity and is presently divided into 3 distinct HIV-1 genetic groups designated major (M), non-M/non-O (N) and outlier (O). Group M, which currently comprises 9 subtypes (A-D, F-H, J and K), at least 34 circulating recombinant forms (CRFs) and several unique recombinant forms (URFs) is responsible for most of the HIV-1 epidemic. Most of the current knowledge of HIV-1 central nervous system (CNS) infection is based on subtype B. However, subtypes other than subtype B account for the majority of global HIV-1 infections. Therefore, we investigated whether subtypes have any influence on cerebrospinal fluid (CSF) markers of HIV-1 CNS infection. CSF HIV-1 RNA, CSF neopterin and CSF white blood cell (WBC) count were measured in patients infected with different HIV-1 subtypes. Using multivariate regression analysis, no differences in the CSF WBC count, neopterin and viral load were found between various HIV-1 subtypes. We did not find any subtype-dependent differences in the markers evaluated in this study.

References

Oct 1, 1986·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·J H McArthur, J C McArthur
Dec 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A J ConradW W Tourtellotte
Aug 17, 1996·Lancet·R W Price
Dec 8, 1998·The Journal of Infectious Diseases·P J KankiS MBoup
Apr 1, 1999·The Journal of Infectious Diseases·J OverbaughJ Bwayo
Jul 31, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M GisslénL Hagberg
Dec 11, 1999·Nucleic Acids Research·R W ShaferM J Gonzales
Feb 26, 2000·Science·S Gartner
Jul 6, 2000·The Journal of Clinical Investigation·D L Kolson, F González-Scarano
Jun 8, 2002·Journal of Neurovirology·Arunima MamidiRoger J Pomerantz
Apr 23, 2003·Journal of Neurovirology·Andrew V AlbrightFrancisco González-Scarano
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Dec 3, 2005·Expert Reviews in Molecular Medicine·Tracy Fischer-Smith, Jay Rappaport
Dec 24, 2005·Current Opinion in Infectious Diseases·Anna Maria Geretti
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ashwin VasanDavid Hunter
Aug 15, 2006·Journal of the International Neuropsychological Society : JINS·Tokugha YepthomiTimothy Flanigan
Nov 17, 2006·The Journal of Infectious Diseases·Serena SpudichRichard W Price
Apr 25, 2007·Journal of Neurovirology·David B CliffordScott Evans
Aug 3, 2007·Nature Clinical Practice. Neurology·Ned SacktorDavid B Clifford
Sep 13, 2007·Journal of Neurovirology·Kevin J LinerKevin R Robertson

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Citations

Feb 1, 2020·Journal of Neurovirology·Sérgio Monteiro de AlmeidaUNKNOWN HIV Neurobehavioral Research Center (HNRC) Group
Nov 21, 2019·Southern African Journal of HIV Medicine·Kaminie MoodleyVinod B Patel

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Methods Mentioned

BETA
PCR
electrophoresis

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