PMID: 9525428Apr 3, 1998Paper

Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
M GisslénBo Svennerholm

Abstract

HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.

References

Sep 1, 1992·Acta Neurologica Scandinavica·N R KarlsenS S Frøland
Apr 1, 1991·AIDS Research and Human Retroviruses·A SönnerborgO Strannegård
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·M GisslénL Hagberg
Nov 1, 1993·Acta Neurologica Scandinavica·O DunlopB Myrvang
Mar 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·N L MichaelD L Birx

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Citations

Mar 8, 2005·Journal of Neurology·Hans-Jürgen von GiesenGabriele Arendt
Nov 30, 2000·Current Infectious Disease Reports·M Holodniy
Dec 3, 1999·Journal of the Neurological Sciences·L AnderssonM Gisslén
Oct 27, 2001·Journal of Clinical Pharmacy and Therapeutics·A Berdowska, K Zwirska-Korczala
Mar 27, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R H EntingJ M Lange
Jul 31, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M GisslénL Hagberg
May 28, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Roseane Porto MedeirosRicardo Sobhie Diaz

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