Cerebrospinal fluid volumetric MRI mapping as a simple measurement for evaluating brain atrophy

European Radiology
J B De VisE T Petersen

Abstract

To assess whether volumetric cerebrospinal fluid (CSF) MRI can be used as a surrogate for brain atrophy assessment and to evaluate how the T2 of the CSF relates to brain atrophy. Twenty-eight subjects [mean age 64 (sd 2) years] were included; T1-weighted and CSF MRI were performed. The first echo data of the CSF MRI sequence was used to obtain intracranial volume, CSF partial volume was measured voxel-wise to obtain CSF volume (VCSF) and the T2 of CSF (T2,CSF) was calculated. The correlation between VCSF/T2,CSF and brain atrophy scores [global cortical atrophy (GCA) and medial temporal lobe atrophy (MTA)] was evaluated. Relative total, peripheral subarachnoidal, and ventricular VCSF increased significantly with increased scores on the GCA and MTA (R = 0.83, 0.78 and 0.78 and R = 0.72, 0.62 and 0.86). Total, peripheral subarachnoidal, and ventricular T2 of the CSF increased significantly with higher scores on the GCA and MTA (R = 0.72, 0.70 and 0.49 and R = 0.60, 0.57 and 0.41). A fast, fully automated CSF MRI volumetric sequence is an alternative for qualitative atrophy scales. The T2 of the CSF is related to brain atrophy and could thus be a marker of neurodegenerative disease. • A 1:11 min CSF MRI volumetric sequence can eval...Continue Reading

References

Apr 24, 1999·Neurology·R BarberJ T O'Brien
Jul 10, 2001·Aging : Clinical and Experimental Research·P H Scheltens
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A HorskáP B Barker
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jun 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greg ZaharchukWilliam P Dillon
Aug 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greg J StaniszR Mark Henkelman
Nov 25, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·L A van de PolP Scheltens
Nov 1, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manus J DonahuePeter C M van Zijl
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·António J Bastos-LeiteFrederik Barkhof
Jul 23, 2008·Practical Neurology·Bo Norrving
Jul 29, 2009·Neurology·P VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 17, 2009·Neurobiology of Aging·Jennifer L WhitwellKeith A Josephs
Oct 12, 2010·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qin Qin
Aug 2, 2011·European Radiology·Esther L G E KoedamMike P Wattjes
Apr 21, 2012·Neurobiology of Aging·Manja LehmannUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 2, 2012·European Radiology·Benjamin S AribisalaJoanna M Wardlaw
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)

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Citations

Nov 8, 2017·Magma·Jolanda M SpijkermanJaco J M Zwanenburg
May 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karl LandheerChristoph Juchem

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