Cerebrospinal fluids containing anti-HSP70 autoantibodies from multiple sclerosis patients augment HSP70-induced proinflammatory cytokine production in monocytic cells

Journal of Neuroimmunology
Shin-ichi YokotaNobuhiro Fujii

Abstract

Anti-heat shock protein 70 (HSP70) autoantibodies are found in cerebrospinal fluids (CSF) from patients with multiple sclerosis. These autoantibodies cross-reacted not only with HSP70 and heat shock cognate protein 70 (HSC70), but also with a bacterial homologue, DnaK. CSF with a high anti-HSP70 autoantibody titer enhanced HSP70-induced proinflammatory cytokine and chemokine production in the human monocytic cell line, THP-1. Thus, anti-HSP70 autoantibodies in the CSF of multiple sclerosis patients may play a pathophysiological role in enhancing inflammation.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Oct 1, 1996·Seminars in Arthritis and Rheumatism·M Tishler, Y Shoenfeld
Mar 1, 2000·Journal of Neuroimmunology·A Bar-OrD A Hafler
Nov 8, 2001·Trends in Immunology·P KivisäkkR M Ransohoff
Mar 20, 2002·Current Neurology and Neuroscience Reports·S Markovic-Plese, H F McFarland
Mar 27, 2002·Nature Reviews. Immunology·Pramod Srivastava
Apr 23, 2002·Nature Reviews. Neuroscience·Bernhard HemmerHans-Peter Hartung
Apr 23, 2002·Journal of Neurology·Jorge Correale, María de los Milagros Bassani Molinas
Sep 14, 2004·Tissue Antigens·R J BinderP Srivastava
Sep 7, 2005·European Journal of Immunology·Stuart K CalderwoodJianlin Gong
Nov 24, 2005·Journal of the Neurological Sciences·Susumu ChibaHiroyuki Matsumoto
May 15, 2007·FEBS Letters·Stuart K CalderwoodJimmy R Theriault

❮ Previous
Next ❯

Citations

Dec 25, 2012·American Journal of Respiratory and Critical Care Medicine·Rehan A KahloonSteven R Duncan
Jun 7, 2012·Molecular Medicine·María José MansillaCarmen Espejo
Feb 5, 2013·Future Microbiology·Davide CossuLeonardo A Sechi
Mar 16, 2011·Biochemistry Research International·Giuseppina TurturiciFabiana Geraci
Aug 12, 2014·Autoimmunity Reviews·Judith FraussenVeerle Somers
Aug 31, 2011·Journal of Neuroimmunology·Burçak VuralGülşen Akman-Demir
Nov 11, 2014·Journal of Neuropathology and Experimental Neurology·Giuseppina TurturiciFabiana Geraci
Jul 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianmin XueSteven R Duncan
Jul 31, 2012·Veterinary Immunology and Immunopathology·Sarah A Moore, Michael J Oglesbee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.