Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Grace L SmithDavid I Rosenthal

Abstract

Cerebrovascular disease is common in head and neck cancer patients, but it is unknown whether radiotherapy increases the cerebrovascular disease risk in this population. We identified 6,862 patients (age > 65 years) from the Surveillance, Epidemiology, and End Results (SEER) -Medicare cohort diagnosed with nonmetastatic head and neck cancer between 1992 and 2002. Using proportional hazards regression, we compared risk of cerebrovascular events (stroke, carotid revascularization, or stroke death) after treatment with radiotherapy alone, surgery plus radiotherapy, or surgery alone. To further validate whether treatment groups had equivalent baseline risk of vascular disease, we compared the risks of developing a control diagnosis, cardiac events (myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft, or cardiac death). Unlike cerebrovascular risk, no difference in cardiac risk was hypothesized. Mean age was 76 +/- 7 years. Ten-year incidence of cerebrovascular events was 34% in patients treated with radiotherapy alone compared with 25% in patients treated with surgery plus radiotherapy and 26% in patients treated with surgery alone (P < .001). After adjusting for covariates, patients treated with...Continue Reading

References

Jun 1, 1987·International Journal of Radiation Oncology, Biology, Physics·T K HeiE J Hall
Oct 27, 1993·JAMA : the Journal of the American Medical Association·S L HancockR T Hoppe
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·C P Derdeyn, W J Powers
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·M BradaD Traish
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·K K AngL J Peters
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lucille D A DorresteijnHarry Bartelink
Dec 6, 2003·JAMA : the Journal of the American Medical Association·Matthew C HullNancy Price Mendenhall
May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Greger NilssonCarl Blomqvist
Mar 17, 2005·Journal of the National Cancer Institute·Sharon H GiordanoJames S Goodwin
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra A PattSharon H Giordano
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Paul D BrownJohn W Hallett
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel C BowersKevin C Oeffinger
May 18, 2006·Journal of the National Cancer Institute·Benjamin D SmithBruce G Haffty
Sep 5, 2006·Lancet·Jean BourhisUNKNOWN Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group
Sep 5, 2006·Journal of Vascular Surgery·Susanna L MatsenG Melville Williams
Sep 21, 2006·Journal of the National Cancer Institute·Benjamin D SmithCary P Gross
Nov 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel C BowersKevin C Oeffinger
Nov 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maartje J HooningFlora E van Leeuwen
Dec 30, 2006·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 8, 2007·Journal of the National Cancer Institute·Maartje J HooningFlora E van Leeuwen

❮ Previous
Next ❯

Citations

Sep 6, 2011·The Journal of Laryngology and Otology·J RimmerC Hopper
Jun 19, 2009·Journal of the National Cancer Institute·Marie L De BruinFlora E van Leeuwen
Nov 12, 2009·Journal of the National Cancer Institute·Dawn L HershmanAlfred I Neugut
Feb 9, 2012·Journal of the National Cancer Institute·Lois B TravisJohn D Boice
Jan 1, 2014·Health Physics·Lois B TravisJohn D Boice
Mar 23, 2010·Cardiovascular Ultrasound·Maria Elena GianicoloMaurizio Portaluri
Aug 7, 2009·Drugs & Aging·Yassine LalamiAhmad Awada
Feb 20, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carlos SuárezAlfio Ferlito
Sep 14, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Antoine DigonnetAlfio Ferlito
Mar 19, 2014·The British Journal of Radiology·K GarcezN Slevin
Nov 11, 2015·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Matthew Christopher WardJohn F Greskovich
Feb 4, 2016·Current Oncology Reports·Konstantinos MarmagkiolisEric H Yang
Aug 3, 2013·International Journal of Radiation Oncology, Biology, Physics·Julian C HongSøren M Bentzen
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Chae-Seon HongTae-Suk Suh
Jul 31, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·I F MaundG A Follows
Aug 21, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Adam C RiegelDavid L Schwartz
May 30, 2012·Seminars in Pediatric Neurology·Sonia Partap
Mar 1, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Pamela CamingueDominique L Roniger
Jan 10, 2012·Seminars in Hematology·Alicia RovóUNKNOWN Late Effects Working Party of the European Group for Blood and Marrow Transplantation
May 17, 2011·International Journal of Radiation Oncology, Biology, Physics·Ching-Chih LeeYung-Sung Huang
Nov 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Bhishamjit S CheraWilliam M Mendenhall
Jan 19, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Martin HallePer Tornvall
Aug 15, 2009·International Journal of Radiation Oncology, Biology, Physics·David I RosenthalK Kian Ang
Jan 28, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Apryl S ScottPeter A S Johnstone
Jul 10, 2009·Pediatric Blood & Cancer·Arnold C Paulino
Dec 1, 2012·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C-N ChuS-W Chen
Jan 25, 2011·Journal of Internal Medicine·M HalleP Tornvall
May 28, 2014·Cancer·Shrujal S BaxiElena B Elkin
Mar 29, 2014·Head & Neck·Atsushi MotegiTetsuo Akimoto
Aug 26, 2014·Journal of Medical Imaging and Radiation Oncology·Chance MatthiesenSalahuddin Ahmad
Jan 17, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Te-Chun HsiehChia-Hung Kao
Mar 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Andrea C LoKaren Goddard
Jun 18, 2015·Journal of Neuro-oncology·Ayal A AizerNils D Arvold
Mar 20, 2010·Journal of the American College of Cardiology·Martin HallePer Tornvall
Sep 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dorothy M GujralChristopher M Nutting

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Lucille D A DorresteijnHarry Bartelink
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Daniel C BowersKevin C Oeffinger
European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Ping ZhouJian Liu
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Reshma JagsiLori J Pierce
© 2022 Meta ULC. All rights reserved