Cerebrovascular effects of prostanoids: in-vitro studies in feline middle cerebral and basilar artery.

Prostaglandins
E T WhalleyM Wahl

Abstract

The effect of prostaglandin (PG) E2, F2 alpha, the thromboxane-A2 mimetic U46619 (9,11-dideoxy-9 alpha,11 alpha-methanoepoxy-prostaglandin F2 alpha) and the prostacyclin mimetic iloprost was investigated in cat middle cerebral and basilar arteries in vitro precontracted with 5-hydroxytryptamine (5-HT) (50nM) in the absence and presence of the cyclooxygenase inhibitor indomethacin or the thromboxane receptor blocker AH23848B [1 alpha (z),2 beta,5 alpha]-(+)-7-[5-[1,1'-(biphenyl)-4-yl] methoxy]-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid). PGF2 alpha and U46619 both produced further concentration-related contractions of basilar and middle cerebral artery, U46619 being approximately 1,000 times more potent than PGF2 alpha. Iloprost produced concentration-related relaxations of precontracted basilar and middle cerebral artery, the mean maximum relaxations produced at a concentration of 1.3 microM being 57.3% and 80.6%, respectively of the contraction produced by 50nM 5-HT. PGE2, 100nM relaxed the basilar and middle cerebral artery, 46.7% and 38.5% respectively. However, at 1 microM, PGE2 caused contraction. Indomethacin, 2.8 microM had no effect on contractile or relaxant responses to any of the prostanoids. Oxyhaemoglobin...Continue Reading

References

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Citations

Feb 4, 2009·Cephalalgia : an International Journal of Headache·T WieneckeM Ashina
Mar 1, 1994·Acta Physiologica Scandinavica·M ArnerE D Högestätt
Nov 1, 1992·American Journal of Obstetrics and Gynecology·T KimuraN Toda
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vikram JadhavTony Jer-Fu Lee
Jan 28, 2004·British Journal of Pharmacology·Richard J DavisRobert A Coleman
Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jose A OspinaDiana N Krause

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