Cerebrovascular endothelial dysfunction mediated by beta-amyloid

Neuroreport
T ThomasG Thomas

Abstract

beta-Amyloid (A beta) toxicity has a critical role in the pathology of Alzheimer's disease (AD) but its function in the neurodegenerative process is not clearly established. Recently, we demonstrated a novel action of beta-amyloid on peripheral blood vessels: endothelial dysfunction through reactive oxygen species. Here we report the direct effect of A beta on cerebrovascular endothelium. Following treatment with A beta 1-40, bovine cerebral arteries showed characteristic features of endothelial dysfunction such as increased contraction to vasoconstrictor and diminished relaxation to endothelium-dependent vasodilators. Electron microscopy revealed significant damage to the endothelium by A beta. Pretreatment with the antioxidant superoxide dismutase (SOD) and PBN (n-tert-butyl-alpha-phenylnitrone) antagonized the effects of A beta. Endothelial damage induced by A beta could produce ischemic and inflammatory changes contributing to the pathology of AD.

References

Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Feb 1, 1995·Brain : a Journal of Neurology·I E SchefferF Cendes
Mar 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S S Sisodia, D L Price
Feb 1, 1997·Experimental Cell Research·E T SuttonT Thomas

❮ Previous
Next ❯

Citations

Jan 24, 2004·Biochimica Et Biophysica Acta·Lee StanyerChristopher C T Smith
May 17, 2005·Neurobiology of Aging·Ahmad A ElesberAmir Lerman
Jan 5, 2002·Neurobiology of Aging·P P Zandi, J C Breitner
May 20, 2000·Annals of the New York Academy of Sciences·T Thomas, J Rhodin
Apr 15, 2010·Molecular Neurodegeneration·Hans H DietrichDavid M Holtzman
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Byung Hee HanGregory Joseph Zipfel
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jennifer Palmer, Seth Love
May 1, 2010·Atherosclerosis. Supplements·Menuka M S Pallebage-GamarallageJohn C L Mamo
Nov 10, 2009·Progress in Lipid Research·R TakechiJ C L Mamo
Jul 22, 2008·Atherosclerosis. Supplements·R TakechiJ C L Mamo
Mar 30, 2010·Neuropathology and Applied Neurobiology·J C PalmerS Love
May 24, 2008·Journal of the American College of Cardiology·Joerg HerrmannAmir Lerman
Mar 26, 1998·Experimental Neurology·F CrawfordM Mullan
Sep 29, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mariangela ChisariSalvatore Salomone
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Aug 8, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J XuC Y Hsu
Apr 7, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nektaria Nicolakakis, Edith Hamel
Dec 9, 2016·Physiology·Livius V d'UscioZvonimir S Katusic
Dec 4, 2010·Circulation Research·Yi Chu, Donald D Heistad
Jan 8, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Susan A Austin, Zvonimir S Katusic
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K NiwaC Iadecola
Mar 26, 2021·Function·Amreen MughalMark T Nelson
Jun 28, 2008·Annals of Clinical Biochemistry·J C L MamoJ Wiltfang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.