Cerebrovascular events after stentless aortic valve replacement during a 9-year follow-up period

The Annals of Thoracic Surgery
Helmut GulbinsJuergen Ennker

Abstract

One major advantage of biologic aortic valve prostheses is their low thrombogenicity compared with mechanical prostheses. The purpose of this study was to evaluate the incidence of cerebrovascular events during long-term follow-up after stentless aortic valve replacement. Between 1996 and 2005, 1,014 patients (mean age, 73 years; range, 20 to 90 years) received stentless aortic valve replacement (Freestyle; Medtronic, Minneapolis, MN) and were included into the systematic follow-up that was closed in 2006 with a completeness of 94.7% and a mean follow-up interval of 3 years (range, 0.5 to 9.8 years). Predictors for freedom from cerebrovascular events were identified by Cox regression. Overall survival was 53% +/- 5% after 8 years (mean, 6.8 +/- 0.2 years). Permanent atrial fibrillation at time of surgery was a strong predictor of impaired survival during follow-up. Freedom from cerebrovascular events during follow-up was 68% +/- 5% at 9 years of follow-up. Multivariate regression analysis revealed previous stroke, age at implant, diabetes mellitus, and carotid lesions as significant risk factors. Especially age older than 75 years was a strong risk factor for cerebrovascular events during follow-up (p = 0.004). Atrial fibrillat...Continue Reading

References

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Citations

Jan 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jonas Amstrup Funder
Jul 7, 2011·Vascular Health and Risk Management·Junjiro Kobayashi
Feb 19, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ajay YadlapatiGabriel Vorobiof
Nov 12, 2013·The Annals of Thoracic Surgery·Jarmo M GunnKari T Kuttila
Jan 10, 2012·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Camille HauvilleRon Waksman
May 3, 2012·Annals of the New York Academy of Sciences·Brian G Hynes, Josep Rodés-Cabau
Nov 15, 2011·Journal of the American College of Cardiology·Benoit DaneaultMartin B Leon
Jun 7, 2014·Stroke; a Journal of Cerebral Circulation·Anders M GreveKristian Wachtell

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