Cerebrovascular events in inflammatory bowel disease patients treated with anti-tumour necrosis factor alpha agents

Journal of Crohn's & Colitis
Konstantinos KarmirisECCO CONFER investigators

Abstract

Cerebrovascular accidents [CVA] have rarely been reported in inflammatory bowel disease [IBD] patients treated with anti-tumour necrosis alpha [anti-TNF alpha] agents. Our aim here was to describe the clinical course of CVA in these patients. This was a European Crohn's and Colitis Organisation [ECCO] retrospective observational study, performed as part of the CONFER [COllaborative Network For Exceptionally Rare case reports] project. A call to all ECCO members was made to report on IBD patients afflicted with CVA during treatment with anti-TNF alpha agents. Clinical data were recorded in a standardised case report form and analysed for event association with anti-TNF alpha treatment. A total of 19 patients were identified from 16 centres: 14 had Crohn's disease, four ulcerative colitis and one IBD colitis unclassified [median age at diagnosis: 38.0 years, range: 18.6-62.5]. Patients received anti-TNF alpha for a median duration of 11.8 months [range: 0-62] at CVA onset; seven had previously been treated with at least one other anti-TNF alpha agent. Complete neurological recovery was observed in 16 patients. Anti-TNF alpha was discontinued in 16/19 patients. However, recurrent CVA or neurological deterioration was not observed ...Continue Reading

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Citations

Mar 24, 2016·Scandinavian Journal of Gastroenterology·Radan KeilJulius Špičák
Dec 15, 2016·Expert Opinion on Biological Therapy·Fabio Salvatore MacalusoMario Cottone
Jun 28, 2016·British Journal of Nursing : BJN·Sue WoodwardChristine Norton
Dec 31, 2019·Frontline Gastroenterology·Rachael SwannGraham Naismith
Aug 11, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sara Salvador-MartínLuis A López-Fernández
Apr 4, 2021·Journal of the Neurological Sciences·José M Ferro, Miguel Oliveira Santos

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